BML-275
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- CAS号:
- 1219168-18-9
- 英文名:
- BML-275
- 英文别名:
- CS-1883;Dorsomorph;BML-275(2HCL);Compound C 2HCl;Dorsomorphin HCl;BML-275,Compound C;BML-275 dihydrochloride;Dorsomorphin-2HCl
BML-275;BML-275 Dorsomorphin 2HCL;Compound C dihydrochloride
- 中文名:
- BML-275
- 中文别名:
- 物质C盐酸盐;DORSOMORPHIN二盐酸盐;BML-275 HCL,物质C盐酸盐;BML-275盐DORSOMORPHIN二盐酸盐;6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶二盐酸盐;6-(4-(2-(哌啶-1-基)乙氧基)苯基)-3-(吡啶-4-基)吡唑并[1,5-A]嘧啶 二盐酸盐
- CBNumber:
- CB72614842
- 分子式:
- C24H27Cl2N5O
- 分子量:
- 472.41008
- MOL File:
- 1219168-18-9.mol
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BML-275化学性质
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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insoluble in EtOH; insoluble in H2O; ≥11.34 mg/mL in 0.9% NS ; ≥39.93 mg/mL in DMSO:H2O=2:1 ; ≥5.91 mg/mL in DMSO
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形态:
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Light yellow powder solid.
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颜色:
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Yellow
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稳定性:
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Hygroscopic
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BML-275性质、用途与生产工艺
Dorsomorphin 2HCl (BML-275, Compound C) 是一种有效的,可逆的,选择性AMPK抑制剂,在无细胞试验中Ki为109 nM,对一些结构相关的激酶,包括ZAPK, SYK, PKCθ,PKA和JAK3没有显著的抑制作用。也会抑制I型BMP受体。Dorsomorphin 可诱导癌细胞系的自噬。
Target | Value |
ALK2
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ALK3
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ALK6
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AMPK
(Cell-free assay)
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109 nM(Ki)
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Dorsomorphin抑制AICAR或者二甲双胍引起的ACC失活,也会减弱肝细胞中AICAR和二甲双胍增加脂肪酸氧化或抑制脂肪生成基因的作用。 Dorsomorphin对AMPK活性的抑制几乎完全抑制了HT-29细胞中的自体吞噬的蛋白质水解作用。此外,Dorsomorphin选择性抑制BMP I型受体ALK2,ALK3和ALK6,并因此阻断BMP介导的SMAD1/5/8磷酸化作用,靶点基因转录和成骨分化。
在成年小鼠体内,Dorsomorphin (10 毫克/千克)降低肝杀菌肽表达的基础水平,并增加血清中铁离子浓度。 Dorsomorphin (0.2 毫克/千克,静脉注射)显著减少LPS 处理的大鼠胸主动脉中VCAM-1 和 ICAM-1的表达。
用途
一种有效、选择性、ATP竞争性的AMPK抑制剂,Ki:109nM。
BML-275
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | S7306 | BML-275 Dorsomorphin (Compound C) 2HCl | 1219168-18-9 | 10mg | 1218.36元 |
2024/08/19 | S7306 | BML-275 Dorsomorphin (Compound C) 2HCl | 1219168-18-9 | 50mg | 3866.79元 |
1219168-18-9, BML-275 相关搜索:
- PI3K
- mTOR
- Akt
- Inhibitors
- PI3K/Akt/mTOR
- 药靶配体
- 小分子抑制剂,天然产物
- 高纯试剂
- C24H25N5O2ClH
- C24H27Cl2N5O
- BML-275盐DORSOMORPHIN二盐酸盐
- 6-(4-(2-(哌啶-1-基)乙氧基)苯基)-3-(吡啶-4-基)吡唑并[1,5-A]嘧啶 二盐酸盐
- DORSOMORPHIN二盐酸盐
- 物质C盐酸盐
- 6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶二盐酸盐
- BML-275 HCL,物质C盐酸盐
- 1219168-18-9
- Dorsomorphin Dihydrochloride BML-275 BML275
- Dorsomorphin (Compound C) dihydrochloride
- Compound C 2HCl
- Dorsomorphin HCl
- BML-275; COMPOUND C; BML275; BML 275
- CS-1883
- 6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE;DIHYDROCHLORIDE
- BML-275;COMPOUND C;BML275;BML 275;BML-275 DIHYDROCHLORIDE;COMPOUND C DIHYDROCHLORIDE;BML275 DIHYDROCHLORIDE;BML 275 DIHYDROCHLORIDE
- BML-275 Dorsomorphin 2HCL
- Dorsomorph
- DORSOMORPHIN 2HCL;BML275.HCL;COMPOUND C
- DORSOMORPHIN (COMPOUND C) 2HCL
- Compound C dihydrochloride
- BML-275(2HCL)
- Dorsomorphin(BML-275)dihydrochloride
- BML-275 dihydrochloride
- 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2)
- Dorsomorphin-2HCl
BML-275
- 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2) Dorsomorphin 2HCl
- BML-275,Compound C
- DorsoMorphin, Dihydrochloride Salt, >99%
- dorsoMorphin (Hydrochloride)
- Dorsomorphin 2HCl
(BML-275 2HCl)