UNC-926
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- CAS号:
- 1184136-10-4
- 英文名:
- UNC-926 Hydochloride
- 英文别名:
- UNC-926;UNC-926 Hydochloride;UNC-926 Hydrochloride;UNC926;UNC-926;UNC 926;(3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;(3-Bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-methanone;Methanone, (3-bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-;(3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride;UNC926,UNC 926,3xMBT,L3MBTL1,Epigenetic Reader Domain,methyl-lysine,H4K20me1,Inhibitor,L3MBTL3,inhibit
- 中文名:
- UNC-926
- 中文别名:
- 化合物UNC 926;化合物UNC 926 HYDROCHLORIDE
- CBNumber:
- CB72652653
- 分子式:
- C16H21BrN2O
- 分子量:
- 337.25
- MOL File:
- 1184136-10-4.mol
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UNC-926化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble2mg/mL, clear (warmed)
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形态:
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powder
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颜色:
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white to light brown
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UNC-926性质、用途与生产工艺
UNC926 是一种 methyl-lysine (Kme) reader domain 抑制剂，可特异性抑制 L3MBTL1，其 IC50 为 3.9 μM。
| Target | Value |
L3MBTL1
()
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3.9 μM(Kd)
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UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC
50
of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.
UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.
用途
UNC-926 is a methyl-lysine reader antagonist; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). UNC-926 selectively inhibits the interaction between L3MBTL13XMBT-H4K20me1 in a peptide pull
down assay.
UNC-926
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | HY-16510 | UNC926 | | 1 mg | 236元 |
| 2024/01/16 | HY-16510 | UNC-926
UNC926 | 1184136-10-4 | 5mg | 590元 |
1184136-10-4, UNC-926 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Amines
- 药靶配体
- C16H21BrN2OHCl
- 化合物UNC 926
- 化合物UNC 926 HYDROCHLORIDE
- 1184136-10-4
- UNC926,UNC 926,3xMBT,L3MBTL1,Epigenetic Reader Domain,methyl-lysine,H4K20me1,Inhibitor,L3MBTL3,inhibit
- Methanone, (3-bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-
- (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
- UNC926;UNC-926;UNC 926
- (3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride
- (3-Bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-methanone
- UNC-926 Hydrochloride
- UNC-926
- UNC-926 Hydochloride