1333210-07-3
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- CAS号:
- 1333210-07-3
- 英文名:
- Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-
- 英文别名:
- SAR7334;TRCP6-IN-1;TRCP6 inhibitor;SAR7334,SAR 7334,TRP Channel,SAR-7334,Inhibitor,inhibit,Transient receptor potential channels;4-(((1R,2R)-2-((R)-3-Aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile;Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-
- 中文名:
- 1333210-07-3
- 中文别名:
- 化合物SAR7334;SAR7334游离态;4-[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氢-1H-茚-1-基]氧基]-3-氯苄腈;4-(((1R,2R)-2-((R)-3-氨基哌啶-1-基)-2,3-二氢-1H-茚-1-基)氧基)-3-氯苯甲腈
- CBNumber:
- CB72668052
- 分子式:
- C21H22ClN3O
- 分子量:
- 367.87
- MOL File:
- 1333210-07-3.mol
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1333210-07-3化学性质
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沸点:
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534.6±50.0 °C(Predicted)
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密度:
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1.30±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in H2O; ≥106.4 mg/mL in EtOH; ≥125.4 mg/mL in DMSO
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酸度系数(pKa):
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10.95±0.20(Predicted)
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1333210-07-3性质、用途与生产工艺
SAR7334是一种新型，高效且可生物利用的TRPC6通道抑制剂。SAR7334在膜片钳实验中阻断了TRPC6电流，IC50为7.9 nM。
| Target | Value |
TPRC6
(Cell-free assay)
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7.9nM
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SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca
2+
influx into cells with IC
50
s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca
2+
entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC
50
of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents.
SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
1333210-07-3
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15699 | SAR7334 | | 1 mg | 909元 |
| 2024/01/25 | HY-15699 | 1333210-07-3
SAR7334 | 1333210-07-3 | 5mg | 2000元 |
1333210-07-3, 1333210-07-3 相关搜索:
- 合成有机化合物配体
- 4-[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氢-1H-茚-1-基]氧基]-3-氯苄腈
- 4-(((1R,2R)-2-((R)-3-氨基哌啶-1-基)-2,3-二氢-1H-茚-1-基)氧基)-3-氯苯甲腈
- 化合物SAR7334
- SAR7334游离态
- 1333210-07-3
- SAR7334,SAR 7334,TRP Channel,SAR-7334,Inhibitor,inhibit,Transient receptor potential channels
- SAR7334
- 4-(((1R,2R)-2-((R)-3-Aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile
- TRCP6-IN-1
- TRCP6 inhibitor
- Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-