24-HYDROXYCHOLESTEROL
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- CAS号:
- 30271-38-6
- 英文名:
- 24-Hydroxycholesterol
- 英文别名:
- Cholest-5-ene-3,24-diol, (3β)-
- 中文名:
- 24-HYDROXYCHOLESTEROL
- 中文别名:
- CBNumber:
- CB72695030
- 分子式:
- C27H46O2
- 分子量:
- 402.65
- MOL File:
- 30271-38-6.mol
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24-HYDROXYCHOLESTEROL化学性质
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沸点:
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513.1±23.0 °C(Predicted)
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密度:
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1.03±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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15.03±0.70(Predicted)
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颜色:
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White to Off-White
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24-HYDROXYCHOLESTEROL性质、用途与生产工艺
24-Hydroxycholesterol 是一种天然的固醇类物质，是n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂。
24S-hydroxycholesterol oxysterol-generating enzyme Cyp46a1 is overexpressed during the angiogenic switch in rat insulin promoter 1-T-antigen 2 (RIP1-Tag2) pNET formation.
Hypoxia inducible factor-1a (HIF-1α) controls the overexpression of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol in a pancreatic neuroendocrine tumor (pNET) model commonly used to study neoangiogenesis. The activation of the HIF-1α-24S-HC axis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1
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islets. 24-hydroxycholesterol levels are increased at 2-4 months in the untreated 5XFAD mouse brain and then became similar to those in the B6SJL mouse brain.
24-HYDROXYCHOLESTEROL
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24-HYDROXYCHOLESTEROL
生产厂家
30271-38-6, 24-HYDROXYCHOLESTEROL 相关搜索:
- Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
- 30271-38-6
- Cholest-5-ene-3,24-diol, (3β)-