2-(3-(2,4-二氟苯基)-4,5-二氢异恶唑-5-基)-1-吗啉乙酮
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- CAS号:
- 1309793-47-2
- 英文名:
- )-CPSI 1306
- 英文别名:
- )-CPSI 1306;)-CPSI 1306;2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one;Ethanone, 2-[3-(2,4-difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)-;2-[3-(3-(2,4-Difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)ethanone
- 中文名:
- 2-(3-(2,4-二氟苯基)-4,5-二氢异恶唑-5-基)-1-吗啉乙酮
- 中文别名:
- 化合物 T17315;化合物CPSI-1306;(±)-CPSI-1306;(±)-CPSI 1306,巨噬细胞迁移抑制因子(MIF)抑制剂;2-(3-(2,4-二氟苯基)-4,5-二氢异恶唑-5-基)-1-吗啉乙酮
- CBNumber:
- CB73036964
- 分子式:
- C15H16F2N2O3
- 分子量:
- 310.3
- MOL File:
- 1309793-47-2.mol
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2-(3-(2,4-二氟苯基)-4,5-二氢异恶唑-5-基)-1-吗啉乙酮化学性质
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沸点:
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453.3±55.0 °C(Predicted)
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密度:
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1.40±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:22.34(Max Conc. mg/mL);71.99(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.64(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);96.68(Max Conc. mM) Ethanol:3.1(Max Conc. mg/mL);9.99(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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-0.91±0.20(Predicted)
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2-(3-(2,4-二氟苯基)-4,5-二氢异恶唑-5-基)-1-吗啉乙酮性质、用途与生产工艺
(±)-CPSI-1306 是具有口服活性的、巨噬细胞游走因子 (MIF) 的拮抗剂。
Mice treated with CPSI-1306 show a significant drop in their blood glucose levels, which is associated with a reduction in serum levels of inflammatory cytokines. As expected, control mice treated with vehicle develop NIDDM as characterized by high serum levels of glucose and inflammatory cytokine. Furthermore, they also show that orally bioavailable CPSI-1306 can be effective in treating this disease. CPSI-1306-induced keratinocyte apoptosis could be appreciated as early as 30 minutes after a single UVB exposure. At 6, 24, and 48 hours following UVB exposure, the CPSI-1306-treated mice show significantly increased expression of cleaved caspase-3 compared with the vehicle-treated mice. CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation.
2-(3-(2,4-二氟苯基)-4,5-二氢异恶唑-5-基)-1-吗啉乙酮
上下游产品信息
上游原料
下游产品
2-(3-(2,4-二氟苯基)-4,5-二氢异恶唑-5-基)-1-吗啉乙酮
生产厂家
1309793-47-2, 2-(3-(2,4-二氟苯基)-4,5-二氢异恶唑-5-基)-1-吗啉乙酮 相关搜索:
- 药靶配体
- (±)-CPSI 1306,巨噬细胞迁移抑制因子(MIF)抑制剂
- 化合物CPSI-1306
- 化合物 T17315
- 2-(3-(2,4-二氟苯基)-4,5-二氢异恶唑-5-基)-1-吗啉乙酮
- (±)-CPSI-1306
- 1309793-47-2
- 2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one
- )-CPSI 1306
- Ethanone, 2-[3-(2,4-difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)-
- 2-[3-(3-(2,4-Difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)ethanone
- )-CPSI 1306