无中文名称
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- CAS号:
- 1668553-26-1
- 英文名:
- A-1210477
- 英文别名:
- CS-2151;CS-2202;A-1210477;Abbvie Mcl-1 Inhibitor;A-1210477;A 1210477;A1210477;A-1210477,inhibit,Inhibitor,A 1210477,Bcl-2 Family,A1210477,Apoptosis;7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid;7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-
- 中文名:
- 无中文名称
- 中文别名:
- 化合物A-1210477;A-1210477,MCL-1抑制剂;MCL-1抑制剂(A-1210477);BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101;7-(5-((4-(4-(N,N-二甲基氨基磺酰)哌嗪-1-基)苯氧基)甲基)-1,3-二甲基-1H-吡唑-4-基)-1-(2-吗啉乙基)-3-(3-(萘-1-基氧基)丙基)-1H-吲哚-2-甲酸;7-[5-[[4-[4-[(二甲基氨基)磺酰基]-1-哌嗪基]苯氧基]甲基]-1,3-二甲基-1H-吡唑-4-基]-1-[2-(4-吗啉基)乙基]-3-[3-(1-萘基氧基)丙基]-1H-吲哚-2-羧酸
- CBNumber:
- CB73040415
- 分子式:
- C46H55N7O7S
- 分子量:
- 850.04
- MOL File:
- 1668553-26-1.mol
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无中文名称化学性质
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沸点:
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1027.4±65.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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insoluble in DMSO; insoluble in H2O; insoluble in EtOH
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形态:
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Powder
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酸度系数(pKa):
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4.43±0.30(Predicted)
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无中文名称性质、用途与生产工艺
A-1210477 是一种有效,选择性的 MCL-1 抑制剂,Ki 值为 0.45 nM。A-1210477 特异性结合 MCL-1,并以 MCL-1 依赖性方式促进癌细胞凋亡 (apoptosis)。
Mcl-1
0.45 nM (Ki)
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Bcl-2
132 nM (Ki)
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Bfl-1
660 nM (Ki)
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Bcl-W
2280 nM (Ki)
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Apoptosis
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A-1210477 (10 μM) reduces the amount of BIM co-immunoprecipitated with MCL-1 antibody, and triggers MCL-1 elevation in a variety of cancer cell lines, including the breast cancer cell line HCC-1806. A-1210477 inhibits MCL-1-NOXA interactions with an IC
50
of approximately 1 μM, while having no effect on BCL-2-BIM or BCL-XL-BCL-XS interactions. The NSCLC cell lines H2110 and H23 are sensitive to A-1210477 with cell viability IC
50
<10 μM, confirming that A-1210477 can kill MCL-1-dependent cell lines.
无中文名称
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-12468 | A-1210477 | | 1 mg | 266元 |
2024/01/25 | HY-12468 | 7-(5-((4-(4-(N,N-二甲基氨基磺酰)哌嗪-1-基)苯氧基)甲基)-1,3-二甲基-1H-吡唑-4-基)-1-(2-吗啉乙基)-3-(3-(萘-1-基氧基)丙基)-1H-吲哚-2-甲酸 A-1210477 | 1668553-26-1 | 5mg | 700元 |
1668553-26-1, 无中文名称 相关搜索:
- Inhibitors
- 细胞生物学试剂
- 抑制剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- C46H55N7O7S
- A-1210477,MCL-1抑制剂
- 化合物A-1210477
- 7-(5-((4-(4-(N,N-二甲基氨基磺酰)哌嗪-1-基)苯氧基)甲基)-1,3-二甲基-1H-吡唑-4-基)-1-(2-吗啉乙基)-3-(3-(萘-1-基氧基)丙基)-1H-吲哚-2-甲酸
- BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101
- MCL-1抑制剂(A-1210477)
- 7-[5-[[4-[4-[(二甲基氨基)磺酰基]-1-哌嗪基]苯氧基]甲基]-1,3-二甲基-1H-吡唑-4-基]-1-[2-(4-吗啉基)乙基]-3-[3-(1-萘基氧基)丙基]-1H-吲哚-2-羧酸
- 1668553-26-1
- A-1210477,inhibit,Inhibitor,A 1210477,Bcl-2 Family,A1210477,Apoptosis
- 1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-
- A-1210477;A 1210477;A1210477
- CS-2151
- CS-2202
- 7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid
- 7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid
- Abbvie Mcl-1 Inhibitor
- A-1210477