CS-2069
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- CAS号:
- 1802088-50-1
- 英文名:
- NCT-501
- 英文别名:
- CS-2069;NCT-501;NCT-501 >=98% (HPLC);Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
- 中文名:
- CS-2069
- 中文别名:
- ALDH1A1抑制剂(NCT-501);8-((4-(环丙基羰基)哌嗪-1-基)甲基)-7-异戊基-1,3-二甲基-1H-嘌呤-2,6(3H,7H)-二酮
- CBNumber:
- CB73043300
- 分子式:
- C21H32N6O3
- 分子量:
- 416.52
- MOL File:
- 1802088-50-1.mol
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CS-2069化学性质
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沸点:
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627.3±65.0 °C(Predicted)
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密度:
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1.37±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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≥20.85 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥11 mg/mL in EtOH
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形态:
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solid
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酸度系数(pKa):
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5.26±0.10(Predicted)
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CS-2069性质、用途与生产工艺
NCT-501 是一种茶碱类的有效醛脱氢酶 1A1 (ALDH1A1) 选择性抑制剂, 抑制 hALDH1A1 时 IC50 值为 40 nM, 选择性超过其它 ALDH 同工酶和其它脱氢酶 (作用于 hALDH1B1, hALDH3A1, 和 hALDH2 时, IC50值 >57 UM)。
NCT-501 shows a 16% decrease in the Cal-27 CisR cell line at 20 nM concentration, though the difference was not statistically significant.
NCT-501 (100 µg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.
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Animal Model:
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5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells)
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Dosage:
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100µg/animal
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Administration:
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Intra-tumorally (i.t); every alternate day for 20 days
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Result:
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Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.
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CS-2069
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-18768 | NCT-501 | | 1 mg | 727元 |
| 2024/01/25 | HY-18768 | CS-2069
NCT-501 | 1802088-50-1 | 5mg | 1600元 |
1802088-50-1, CS-2069 相关搜索:
- 细胞生物学试剂
- 8-((4-(环丙基羰基)哌嗪-1-基)甲基)-7-异戊基-1,3-二甲基-1H-嘌呤-2,6(3H,7H)-二酮
- ALDH1A1抑制剂(NCT-501)
- 1802088-50-1
- 8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
- Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501
- NCT-501 >=98% (HPLC)
- 1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
- CS-2069
- NCT-501