N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺
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- CAS号:
- 179068-02-1
- 英文名:
- PHCCC
- 英文别名:
- (-) PHCCC;PHCCC >=97% (HPLC);(7Z)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide;7-(Hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide;7,7a-Dihydro-7-(hydroxyimino)-N-phenylbenzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide;Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-phenyl-;Cyclopropa[b][1]benzopyran-1a(1H)-carboxamide,7,7a-dihydro-7-(hydroxyimino)-N-phenyl-,(7Z)-;allosteric,disease,Metabotropic glutamate receptors,Inhibitor,PHCCC,neurons,neuroprotective,mGluR,Parkinson's,inhibit
- 中文名:
- N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺
- 中文别名:
- PHCCC游离态;化合物PHCCC;PHCCC,MGLU 4的变构增强剂;N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺;7-(肟基)-N-苯基-7,7A-二氢环丙烷[B]苯并哌喃-1A(1H)-酰胺
- CBNumber:
- CB73128919
- 分子式:
- C17H14N2O3
- 分子量:
- 294.3
- MOL File:
- 179068-02-1.mol
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N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺化学性质
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺性质、用途与生产工艺
PHCCC 是一种 I 型 mGluR (Group I mGluR) 拮抗剂，IC50 为 3 μM，PHCCC 也是 mGlu4 受体选择性正向调节剂。具有抗帕金森病作用。
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Group I mGluR receptors
3 μM (IC
50
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PHCCC potentiated the effect of L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) in inhibiting transmission at the striatopallidal synapse.
PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model.
N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺
上下游产品信息
上游原料
下游产品
N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺
生产厂家
179068-02-1, N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺 相关搜索:
- 合成有机化合物配体
- PHCCC,MGLU 4的变构增强剂
- 7-(肟基)-N-苯基-7,7A-二氢环丙烷[B]苯并哌喃-1A(1H)-酰胺
- PHCCC游离态
- 化合物PHCCC
- N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺
- 179068-02-1
- allosteric,disease,Metabotropic glutamate receptors,Inhibitor,PHCCC,neurons,neuroprotective,mGluR,Parkinson's,inhibit
- 7-(Hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide
- (-) PHCCC
- (7Z)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide
- Cyclopropa[b][1]benzopyran-1a(1H)-carboxamide,7,7a-dihydro-7-(hydroxyimino)-N-phenyl-,(7Z)-
- PHCCC >=97% (HPLC)
- Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-phenyl-
- 7,7a-Dihydro-7-(hydroxyimino)-N-phenylbenzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide