1-甲苯磺酰-1H-吲哚-2-甲酸乙酯
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- CAS号:
- 132819-92-2
- 英文名:
- 1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester
- 英文别名:
- NOD-IN-1;MDK19922;NOD inhibitor 1;ethyl 1-(4-methylphenyl)sulfonylindole-2-carboxylate;NOD-IN-1; COMPOUND 4; MDK19922; MDK 19922; MDK-19922.;NODIN1,inhibit,NOD IN 1,Inhibitor,NOD-like Receptor (NLR);1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester;1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester
- 中文名:
- 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯
- 中文别名:
- 化合物NOD-IN-1;1-甲苯磺酰-1H-吲哚-2-甲酸乙酯
- CBNumber:
- CB73145909
- 分子式:
- C18H17NO4S
- 分子量:
- 343.4
- MOL File:
- 132819-92-2.mol
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1-甲苯磺酰-1H-吲哚-2-甲酸乙酯化学性质
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熔点:
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98-99 °C
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沸点:
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523.3±52.0 °C(Predicted)
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密度:
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1.27±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
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形态:
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A crystalline solid
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1-甲苯磺酰-1H-吲哚-2-甲酸乙酯性质、用途与生产工艺
NOD-IN-1 (MDK19922, Compound 4) 是一种有效的 nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) 和 NOD2 的混合抑制剂，对应的IC50值分别为5.74 μM和6.45 μM。
IC50: 5.74 μM (NOD1), 6.45 μM (NOD2)
NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC
50
(NOD1)=5.74 μM; IC
50
(NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets.
1-甲苯磺酰-1H-吲哚-2-甲酸乙酯
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100691 | 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯
NOD-IN-1 | 132819-92-2 | 1mg | 800元 |
| 2024/01/25 | HY-100691 | 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯
NOD-IN-1 | 132819-92-2 | 10mM * 1mLin DMSO | 1130元 |
132819-92-2, 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯 相关搜索:
- 药靶配体
- 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯
- 化合物NOD-IN-1
- 132819-92-2
- ethyl 1-(4-methylphenyl)sulfonylindole-2-carboxylate
- NODIN1,inhibit,NOD IN 1,Inhibitor,NOD-like Receptor (NLR)
- 1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester
- MDK19922
- NOD-IN-1; COMPOUND 4; MDK19922; MDK 19922; MDK-19922.
- NOD inhibitor 1
- NOD-IN-1
- 1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester