YU238259
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- CAS号:
- 1943733-16-1
- 英文名:
- YU238259
- 英文别名:
- YU238259;YU-238259;YU 238259;inhibit,Inhibitor,DNA-dependent protein kinase,DNA-PK,YU 238259,YU-238259,YU238259;N-(2-(5-Chloropyridin-2-yl)ethyl)-4-(((4-methoxyphenyl)sulfonamido)methyl)benzamide;Benzamide, N-[2-(5-chloro-2-pyridinyl)ethyl]-4-[[[(4-methoxyphenyl)sulfonyl]amino]methyl]-
- 中文名:
- YU238259
- 中文别名:
- 化合物YU238259;N-(2-(5-氯吡啶-2-基)乙基)-4-((4-甲氧基苯磺酰胺基)甲基)苯甲酰胺
- CBNumber:
- CB73303239
- 分子式:
- C22H22ClN3O4S
- 分子量:
- 459.95
- MOL File:
- 1943733-16-1.mol
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YU238259化学性质
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密度:
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1.323±0.06 g/cm3(Predicted)
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储存条件:
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Inert atmosphere,Room Temperature
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溶解度:
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DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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11.46±0.50(Predicted)
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YU238259性质、用途与生产工艺
YU238259 是一种同源依赖性 DNA 修复 (HDR) 抑制剂，可用于癌症研究。
YU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD
50
of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss.
YU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice.
YU238259
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-19977 | YU238259 | | 1 mg | 419元 |
| 2024/01/25 | HY-19977 | YU238259
YU238259 | 1943733-16-1 | 5mg | 1100元 |
1943733-16-1, YU238259 相关搜索:
- 化合物YU238259
- N-(2-(5-氯吡啶-2-基)乙基)-4-((4-甲氧基苯磺酰胺基)甲基)苯甲酰胺
- 1943733-16-1
- inhibit,Inhibitor,DNA-dependent protein kinase,DNA-PK,YU 238259,YU-238259,YU238259
- N-(2-(5-Chloropyridin-2-yl)ethyl)-4-(((4-methoxyphenyl)sulfonamido)methyl)benzamide
- Benzamide, N-[2-(5-chloro-2-pyridinyl)ethyl]-4-[[[(4-methoxyphenyl)sulfonyl]amino]methyl]-
- YU-238259;YU 238259
- YU238259