DHPS抑制剂
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- CAS号:
- 150417-90-6
- 英文名:
- GC7 Sulfate
- 英文别名:
- GC7 Sulfate;GC7 Sulfate,GC-7 Sulfate
- 中文名:
- DHPS抑制剂
- 中文别名:
- GC7硫酸盐;DHPS抑制剂;化合物 T11372;DHPS抑制剂(GC7 SULFATE)
- CBNumber:
- CB73386481
- 分子式:
- C8H22N4O4S
- 分子量:
- 270.35
- MOL File:
- 150417-90-6.mol
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DHPS抑制剂化学性质
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储存条件:
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Store at -20°C
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溶解度:
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10 mM AcOH: soluble
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形态:
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A solid
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DHPS抑制剂性质、用途与生产工艺
GC7 Sulfate 是一种脱氧嘌呤合成酶 (DHPS) 抑制剂。
The treatment of MYCN2 (±Dox) and BE(2)-C cells with GC7 Sulfate for 72 h at various concentrations (0.1 to 100 μM) significantly reduces the number of viable cells in a dose-dependent manner. In MYCN2 cells, 5 μM of GC7 Sulfate inhibits cell viability by ~40 and ~60 %, respectively, compare to untreated control cells. BE(2)-C cells require 25 μM of GC7 Sulfate to reduce cell viability by ~50 %. Exposure to 10 and 100 μM GC7 for 72 h clearly decreases the levels of total retinoblastoma (Rb) and phosphorylated Rb as well as of Cdk4 protein, and increases the levels of p21 protein. Between 0 and 20 μM, GC7 Sulfate induces little cytotoxicity in HCC cells, while higher concentrations of GC7 Sulfate (50 to 100 μM) significantly inhibit the viability of all five HCC cell lines tested. Newly synthesized
3
H-labeled hypusine of eIF5A1/eIF5A2 is rarely detected after 20 μM GC7 Sulfate treatment, compare to untreated control. The activity of [
3
H]-spermidine incorporated into HCC cells is significantly decreased by 20 μM GC7 Sulfate or higher concentration.
DHPS抑制剂
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-108314A | DHPS抑制剂 GC7 Sulfate | 150417-90-6 | 1mg | 550元 |
2024/01/25 | HY-108314A | DHPS抑制剂 GC7 Sulfate | 150417-90-6 | 5mg | 1200元 |
150417-90-6, DHPS抑制剂 相关搜索:
- 药靶配体
- 标准品
- 对照品
- 细胞生物学试剂
- GC7硫酸盐
- 化合物 T11372
- DHPS抑制剂
- DHPS抑制剂(GC7 SULFATE)
- 150417-90-6
- GC7 Sulfate,GC-7 Sulfate
- GC7 Sulfate