CPD1599
|
|
- CAS号:
- 1883650-96-1
- 英文名:
- CDDO-3-P-Im
- 英文别名:
- CPD1599;CPDB1599;CDDO-3-P-Im;CDDO-2P-Imidazolide;Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(2-pyridinyl)-1H-imidazol-1-yl]-
- 中文名:
- CPD1599
- 中文别名:
- 化合物 T13602;化合物CDDO-2P-IM
- CBNumber:
- CB73956895
- 分子式:
- C39H46N4O3
- 分子量:
- 618.81
- MOL File:
- 1883650-96-1.mol
|
|
|
CPD1599化学性质
-
沸点:
-
766.1±70.0 °C(Predicted)
-
|
-
密度:
-
1.25±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 250 mg/mL (404.00 mM)
-
|
-
酸度系数(pKa):
-
1.60±0.19(Predicted)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
White to off-white
-
|
CPD1599性质、用途与生产工艺
CDDO-2P-Im 是 CDDO 咪唑胺类似物,具有化学预防作用。CDDO-2P-Im 可降低小鼠肺癌模型肺肿瘤的大小和严重程度。
CDDO-2P-Im (100 nM; 4 days) induces differentiation of U937 cells at 100 nM.
CDDO-2P-Im suppresses NO production in RAW264.7 cells with an IC
50
of 5.8 nM.
Apoptosis Analysis
Cell Line:
|
U937 cells
|
Concentration:
|
30 nM, 100 nM
|
Incubation Time:
|
4 days
|
Result:
|
Induced differentiation of U937 cells at 100 nM.
|
CDDO-2P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-2P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-2P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.
Animal Model:
|
Seven week-old female A/J mice
|
Dosage:
|
50 mg/kg, 200 mg/kg
|
Administration:
|
Diet; for 16 weeks
|
Result:
|
Decreased the number, the size and the severity of tumors.
|
CPD1599
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-135953 | CDDO-3P-Im | | 1 mg | 952元 |
2024/08/19 | HY-135953 | CPD1599 CDDO-3P-Im | 1883650-96-1 | 5mg | 2500元 |
1883650-96-1, CPD1599 相关搜索:
- 抑制剂
- 化合物CDDO-2P-IM
- 化合物 T13602
- 1883650-96-1
- Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(2-pyridinyl)-1H-imidazol-1-yl]-
- CDDO-2P-Imidazolide
- CPDB1599
- CPD1599
- CDDO-3-P-Im