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L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
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- CAS号:
- 134448-10-5
- 英文名:
- CA-074
- 英文别名:
- CA-074;CA-074(OH);CA 074 TFA;CA-074 >=99% (TLC);CATHEPSIN B INHIBITOR III;INHIBITOR FOR CATHEPSIN B;L-trans-Epoxysuccinyl(propylamide)-Ile-Pro;L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE;L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OH;CA-074(L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide)
- 中文名:
- L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
- 中文别名:
- 化合物 T21509;CA074 TFA盐;L-反式-环氧丁二酰基(丙胺)-IP;CATHEPSIN B抑制剂(CA-074);L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH;(L-3-反式-(丙基氨基甲酰基)环氧乙烷-2-羰基)-L-异亮氨酰-L-脯氨酸;N-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-羰基)-L-异亮氨酰-L-脯氨酸;CA-074(L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE);(S)-1-((2S,3S)-3-甲基-2-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-甲酰胺基)戊酰基)吡咯烷-2-羧酸
- CBNumber:
- CB7400409
- 分子式:
- C18H29N3O6
- 分子量:
- 383.44
- MOL File:
- 134448-10-5.mol
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L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE化学性质
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沸点:
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728.9±60.0 °C(Predicted)
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密度:
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1.267±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in methanol at 1mg/ml. Also soluble in DMSO or ethanol.
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形态:
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solid
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酸度系数(pKa):
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3.43±0.20(Predicted)
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L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE性质、用途与生产工艺
CA-074是组织蛋白酶B (cathepsin B) 的有效抑制剂, Ki 值为2 to 5 nM。
Ki: 2 to 5 nM (Cathepsin B)
CA-074 is a synthetic analogue of E-64, a natural peptidyl epoxide that irreversibly inhibits most known lysosomal cysteine proteinases, and is developed by means of rational drug design, exploiting the dipeptidylcarboxypeptidase activity of cathepsin B. CA-074 can be used to selectively inhibit cathepsin B within living cells, as long as the experimental conditions permit significant fluid-phase endocytosis of the drug. CA-074 inhibits cathepsin B with a K
i
of 2 to 5 nM, whereas the initial K
i
s for cathepsin H and L are about 40-200 μM. CA-074 exhibits 10000-30000 times greater inhibitory effects on purified rat cathepsin B than on cathepsin H and L.
Intraperitoneally injection of compound CA-074 into rats potently and selectively inhibits cathepsin B activity. Intravenously administration of CA-074 immediately after the ischaemic insult saves 67% of CA1 neurons from delayed neuronal death on day 5 in eight monkeys undergoing 20 min brain ischaemia: the extent of inhibition is excellent in three of eight and good in five of eight monkeys.
L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-103350 | L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE CA-074 | 134448-10-5 | 1mg | 900元 |
2024/01/25 | HY-103350 | L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE CA-074 | 134448-10-5 | 10mM * 1mLin DMSO | 2278元 |
L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
生产厂家
134448-10-5, L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE 相关搜索:
- Inhibitor
- Pepetides
- peptides
- 多肽
- 目录肽
- 抑制剂
- 细胞生物学试剂
- BioChemical
- Apoptosis and Cell Cycle
- Cell Signaling and Neuroscience
- Cell Biology
- Cathepsins and Granzymes
- Inhibitors
- C18H29N3O6
- CA074 TFA盐
- L-反式-环氧丁二酰基(丙胺)-IP
- 化合物 T21509
- N-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-羰基)-L-异亮氨酰-L-脯氨酸
- CA-074(L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE)
- L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH
- (S)-1-((2S,3S)-3-甲基-2-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-甲酰胺基)戊酰基)吡咯烷-2-羧酸
- CATHEPSIN B抑制剂(CA-074)
- (L-3-反式-(丙基氨基甲酰基)环氧乙烷-2-羰基)-L-异亮氨酰-L-脯氨酸
- 134448-10-5
- CA 074 TFA
- (S)-1-((2S,3S)-3-Methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)pyrrolidine-2-carboxylic acid
- CA-074(OH)
- CA-074(L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide)
- CA-074 >=99% (TLC)
- L-Proline, N-[[(2S,3S)-3-[(propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-
- N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
- L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OH
- L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
- [L-3-TRANS-(PROPYLCARBOMOYL)OXIRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE
- (L-3-TRANS-(PROPYLCARBAMYL)OXIRANE-2-CARBONYL)-L-ISOLEUCYL-L-PROLINE
- [L-3-TRANS-(PROPYLCARBAMOYL)OXIRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE
- CA-074
- CATHEPSIN B INHIBITOR III
- INHIBITOR FOR CATHEPSIN B
- N-(L-3-trans-PropylcarbaMoyl-oxirane-2-carbonyl)-Ile-Pro-OH, CA-074, L-trans-Epoxysuccinyl(propylaMide)-Ile-Pro-OH
- L-trans-Epoxysuccinyl(propylamide)-Ile-Pro
- N-(L-3-TRANS-PROPYLCARBAMOYL-OXIRANE-2-CARBONYL)-ILE-PRO-OH