阿拉磷
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- CAS号:
- 60668-24-8
- 英文名:
- (S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID
- 英文别名:
- ALAPHOSPHIN;ALAFOSFALIN;Alafosfalin >97%;L-ALANYL-L-ALA(P)-OH;L-ALANYL-L-1-AMINOETHYLPHOSPHONIC ACID;(S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID;((R)-1-((S)-2-Aminopropanamido)ethyl)phosphonic acid;[(1R)-1-[[(2S)-2-Aminopropanoyl]amino]ethyl]phosphonic acid;L-ALANYL-L-ALA(P)-OH, (S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID;Phosphonic acid, P-[(1R)-1-[[(2S)-2-amino-1-oxopropyl]amino]ethyl]-
- 中文名:
- 阿拉磷
- 中文别名:
- 阿拉磷;化合物 T25021;L-丙氨酰-L-1-氨基乙基膦酸
- CBNumber:
- CB7437290
- 分子式:
- C5H13N2O4P
- 分子量:
- 196.14
- MOL File:
- 60668-24-8.mol
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阿拉磷化学性质
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熔点:
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295-296° (dec)
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比旋光度:
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D20 -44.0° (c = 1 in H2O)
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密度:
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1.395±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Methanol (Slightly), Water (Sligthly)
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酸度系数(pKa):
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2.60±0.10(Predicted)
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形态:
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powder
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颜色:
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colorless or white
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旋光性 (optical activity):
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[α]20/D 45±2°, c = 1% in H2O
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Merck:
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13,202
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BRN:
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4801790
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阿拉磷性质、用途与生产工艺
Alafosfalin 是一种细胞壁生物合成抑制剂。Alafosfalin 是一种磷酸二肽，具有抗菌 (antibacterial) 特性。
Alafosfalin is highly active against
Escherichia coli
and moderately active against
Serratia
,
Klebsiella
,
Enterobacter
, and
Citrobacter
, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive
Proteus
,
Pseudomonas
, and
Acinetobacter
.
After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t
1/2
) of approximately 20 minutes.
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Animal Model:
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Pairs of male SpragueDawley rats (250 to 350 g)
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Dosage:
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20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis)
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Administration:
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Administrated by s.c.
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Result:
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Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes.
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阿拉磷
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阿拉磷
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阿拉磷国内生产厂家
60668-24-8, 阿拉磷 相关搜索:
- BioChemical
- Antibiotics
- Antibiotics A-F
- Antibiotics A to Z
- C5H13N2O4P
- 化合物 T25021
- L-丙氨酰-L-1-氨基乙基膦酸
- 阿拉磷
- 60668-24-8
- ((R)-1-((S)-2-Aminopropanamido)ethyl)phosphonic acid
- Phosphonic acid, P-[(1R)-1-[[(2S)-2-amino-1-oxopropyl]amino]ethyl]-
- Alafosfalin >97%
- L-ALANYL-L-ALA(P)-OH, (S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID
- [(1R)-1-[[(2S)-2-Aminopropanoyl]amino]ethyl]phosphonic acid
- (S)-Alanyl-(R)-1-aminoethylphosphonic acid, Alafosfalin, Alaphosphin
- ALAPHOSPHIN
- ALAFOSFALIN
- L-ALANYL-L-ALA(P)-OH
- L-ALANYL-L-1-AMINOETHYLPHOSPHONIC ACID
- (S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID