甲磺酸双氢麦角汀
|
|
|
- CAS号:
- 24730-10-7
- 英文名:
- DIHYDROERGOCRISTINE MESYLATE
- 英文别名:
- C13168;DHEC (mesylate);dihydroergocristinmesilat;DIHYDROERGOCRISTINE MESYLATE;Dihydroergocristine mesilate CRS;DIHYDROERGOCRISTINE METHANESULFONATE;Dihydroergocristine mesilate (D1945000);dihydroergocristine methanesulfonate salt;DIHYDROERGOCRYSTINE METHANESULFONATE SALT;9,10-dihydro-ergocristinmonomethanesulfonate(salt)
- 中文名:
- 甲磺酸双氢麦角汀
- 中文别名:
- 甲磺酸双氢麦角汀;甲磺酸二氢麦角新碱;甲磺酰双氢麦角克碱;双氢麦角汀 甲磺酸盐;二氢麦角亭甲烷硫酸盐;二氢麦角新碱甲磺酸盐;二氢麦角碱(甲磺酸盐);甲磺酸双氢麦角汀 EP标准品
- CBNumber:
- CB7447208
- 分子式:
- C36H45N5O8S
- 分子量:
- 707.84
- MOL File:
- 24730-10-7.mol
|
|
|
甲磺酸双氢麦角汀化学性质
-
熔点:
-
210 °C
-
|
-
储存条件:
-
Store at RT
-
|
-
溶解度:
-
H2O: 10 mg/mL
-
|
甲磺酸双氢麦角汀性质、用途与生产工艺
Dihydroergocristine mesylate (DHEC mesylate) 是γ-secretase (GSI) 的抑制剂, 可减少阿尔茨海默氏病淀粉样蛋白 β 肽 (amyloid-β) 的产生, 与 γ-secretase 和 Nicastrin 结合的平衡解离常数 (Kd) 值分别为 25.7 nM 和 9.8 μM。
Dihydroergocristine (DHEC) (2-20 μM; 24 hours) has an IC
50
value of 25 μM for inhibiting the activity of γ-secretase in T100 cells without affecting cell viability.
Dihydroergocristine (2-20 μM; 24 hours) inhibits cellular Aβ production and causes a dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293 and decreases γ-secretase activity in fibroblast cells.
Western Blot Analysis
|
Cell Line:
|
WT HEK293 cells; Fibroblast cells
|
|
Concentration:
|
2 μM, 5 μM, 10 μM, 20 μM
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Increased APP-CTFs accumulation in a dose-dependent manner.
|
甲磺酸双氢麦角汀
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-N2319 | 甲磺酸双氢麦角汀
Dihydroergocristine mesylate | 24730-10-7 | 5mg | 1500元 |
| 2024/01/25 | HY-N2319 | 甲磺酸双氢麦角汀
Dihydroergocristine mesylate | 24730-10-7 | 10mM * 1mLin DMSO | 2336元 |
甲磺酸双氢麦角汀
生产厂家
全球有 72家供应商
甲磺酸双氢麦角汀国内生产厂家
24730-10-7, 甲磺酸双氢麦角汀 相关搜索:
- Serotonin receptor
- Neat Compounds
- Drugs&Metabolites
- Drugs of Abuse
- D
- Chemical Structure
- AlkaloidsAlphabetic
- ErgotamineForensic and Veterinary Standards
- DID - DINDrugs of Abuse
- Organics
- 化工原料
- DID - DIN
- Analytical Standards
- Analytical Chromatography Product Catalog
- Alphabetic
- C35H41N5O5CH4O3S
- C35H41N5O5CH3SO3H
- C36H45N5O8S
- 甲磺酸二氢麦角新碱
- 二氢麦角新碱甲磺酸盐
- 甲磺酸双氢麦角汀 EP标准品
- 二氢麦角碱(甲磺酸盐)
- 双氢麦角汀 甲磺酸盐
- 二氢麦角亭甲烷硫酸盐
- 甲磺酰双氢麦角克碱
- 甲磺酸双氢麦角汀
- 24730-10-7
- Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'α,10α)-, methanesulfonate (1:1)
- Dihydroergotamine Mesilate EP Impurity E as Mesilate
- β-amyloid peptide,Amyloid-β,Abeta,Dihydroergocristine,inhibit,Dihydroergocristine mesylate,Inhibitor,DHEC
- Dihydroergocristine mesilate (D1945000)
- DHEC (mesylate)
- Dihydroergocristine mesilate CRS
- (5'A,10A)-9,10-DIHYDRO-12'-HYDROXY-2'-(1-METHYLETHYL)-5'-(PHENYLMETHYL)-ERGOTAMAN-3',6',18-TRIONE MESYLATE
- DIHYDROERGOCRYSTINE METHANESULFONATE SALT
- DIHYDROERGOCRISTINE METHANESULFONATE
- DIHYDROERGOCRISTINE MESYLATE
- Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt)
- dihydroergocristine methanesulfonate salt
- (5,10a)-9,10-Dihydro-12hydroxy-2(1-methylethyl)-5(phenylmethyl)-ergotamane-3618-trionemesylate]
- DIHYDROERGOCRISTINE METHANESULFONATE ERG OT ALKALOID, VASOC
- 5'alpha-benzyl-9,10alpha-dihydro-12'-hydroxy-2'-isopropylergotaman-3',6',18-trione monomethanesulphonate
- ergotamane-3’,6’,18-trione,9,10-dihydro-12’-hydroxy-2’-(1-methylethyl)-5’-(phe
- dihydroergocristinmesilat
- 9,10-dihydro-ergocristinmonomethanesulfonate(salt)
- (5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trionemesylate
- C13168
- (5'alpha, 10alpha)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trione mesylate
- (5’-alpha,10-alpha)-nylmethyl)monomethanesulfonate(salt)