金精三羧酸
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- CAS号:
- 4431-00-9
- 英文名:
- AURINTRICARBOXYLIC ACID
- 英文别名:
- ATA;SKL331;e)-6-oxo-;aluminonfreeacid;TIMTEC-BB SBB005410;AURINTRICARBONIC ACID;aurintricarboxylicaci;LABOTEST-BB LT00080677;AURINTRICARBOXYLIC ACID;aurinetricarboxylic acid
- 中文名:
- 金精三羧酸
- 中文别名:
- 金黄三羧酸;金黄三羧羧;金精三羧酸;金精三羧酸|ATA
- CBNumber:
- CB7463004
- 分子式:
- C22H14O9
- 分子量:
- 422.34
- MOL File:
- 4431-00-9.mol
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金精三羧酸性质、用途与生产工艺
Aurintricarboxylic acid 是高效的，αβ- 亚甲基 -ATP 敏感选择性 P2X1Rs 和 P2X3Rs 变构拮抗剂，对 rP2X1R 和 rP2X3R 作用的 IC50 值分别为 8.6 nM 和 72.9 nM。Aurintricarboxylic acid 是一种有效的抗流感剂，通过直接抑制神经氨酸酶 (neuraminidase) 作用。Aurintricarboxylic acid 也是拓扑异构酶 II 和凋亡抑制剂。Aurintricarboxylic acid 是选择性的 TWEAK-Fn14 信号通路抑制剂。Aurintricarboxylic acid 也是一种胱硫醚-γ-裂解酶 (CSE) 抑制剂，其 IC50 值为 0.6 μM。Aurintricarboxylic acid 是能够调节 miRNA 功能的 miRNA 调节剂。
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Topoisomerase II
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rP2X1R
8.6 nM (IC
50
)
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rP2X3R
72.9 nM (IC
50
)
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Apoptosis
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miRNA
0.47 μM (IC
50
)
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Aurintricarboxylic acid strongly inhibits rP2X1Rs and rP2X3Rs with IC
50
values of 8.6 nM and 72.9 nM, respectively, and more weakly inhibits P2X2/3Rs, P2X2Rs, P2X4Rs or P2X7Rs.
Aurintricarboxylic acid inhibition of ATP-induced currents is concentration dependent.
Aurintricarboxylic acid is a non-competitive antagonist of P2X3R.
Aurintricarboxylic acid can inhibit the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and vaccinia virus.
Aurintricarboxylic acid protects MDCK cells from infection with influenza A strains PR8, NY or N.
Aurintricarboxylic acid inhibits replication of influenza A and B viruses.
Aurintricarboxylic acid inhibits neuraminidase activities of influenza A and B viruses.
Aurintricarboxylic acid inhibits TWEAK-Fn14-mediated NF-κB activation.
Aurintricarboxylic acid (10 μM;0.5-2 hours) suppresses TWEAK-Fn14-mediated NF-κB, Akt, and Src phosphorylation in GBM cells.
Aurintricarboxylic acid blocks TWEAK-stimulated Rac1 activation and TRAF2 recruitment to Fn14 cytoplasmic domain in glioma cells.
Aurintricarboxylic acid represses TWEAK-stimulated glioma cell migration and invasion without causing cell cytotoxicity.
Aurintricarboxylic acid (Compound 8) cannot regulate loading of endogenous let-7 onto AGO2 inside cultured cells, whereas can inhibit RISC loading of exogenous siRNA.
Western Blot Analysis
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Cell Line:
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T98G, A172, GBM44 glioma cells
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Concentration:
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10 μM
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Incubation Time:
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0.5 hour, 1 hour, 2 hours
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Result:
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Abrogated TWEAK activation of downstream signals including phosphorylation of the NF-κB family member p65, Akt, and Src in all three GBM cell lines.
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化学性质
桔红色至棕红色粉末。熔点220-225℃（分解）。易溶于水，微溶于乙醇，不溶于丙酮。
用途
铝试剂的中间体。
生产方法
水杨酸与甲醛反应得到亚甲基二水杨酸，再将其与水杨酸、亚硝酰硫酯混合反应，得金黄三羧酸。
金精三羧酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-122575 | 金精三羧酸
Aurintricarboxylic acid | 4431-00-9 | 100mg | 550元 |
| 2024/01/25 | HY-122575 | 金精三羧酸
Aurintricarboxylic acid | 4431-00-9 | 10mM * 1mLin DMSO | 610元 |
金精三羧酸
生产厂家
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金精三羧酸国内生产厂家
4431-00-9, 金精三羧酸 相关搜索:
- Colours, Dyes, Indicators & Pigments
- 化工中间体
- 抑制剂
- 有机化工原料
- 通用生化试剂-生物染色剂与化学指示剂
- 化学试剂
- 生化试剂-色素类
- 色素类
- Apoptosis and Cell Cycle
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- DNA Repair Regulators
- DNA metabolism
- C22H14O9
- 金精三羧酸|ATA
- 金黄三羧酸
- 金黄三羧羧
- 金精三羧酸
- 4431-00-9
- Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem
- 5-[(3-carboxy-4-hydroxyphenyl)-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid
- SKL331
- Aurintricarboxylic Acids (Technical Grade)
- aurintricarboxylicaci
- Benzoic acid, 3,3'-[(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis[6-hydroxy-
- bis(2-hydroxybenzoic acid)
- 5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)
- e)-6-oxo-
- aluminonfreeacid
- 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-benzoicaci
- 1,4-cyclohexadiene-1-carboxylicacid,3-(bis(3-carboxy-4-hydroxyphenyl)methylen
- AURINTRICARBOXYLIC ACID
- 5,5'-((3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)Methylene)bis(2-hydroxybenzoic acid)
- Aurintricarboxylic acid,85%,tech.
- 5,5'-[(3-Carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis(2-hydroxybenzoic acid)
- 1-Oxo-4-[bis(3-carboxy-4-hydroxyphenyl)methylene]-2,5-cyclohexadiene-2-carboxylic acid
- Aurintricarboxylic acid, tech., 85%
- AURINTRICARBONIC ACID
- Aurintricarboxylic Acid (Ata)
- AURINTRICARBOXYLIC ACID FREE ACIDPRACTIC AL GRADE
- aurinetricarboxylic acid
- 5,5-(3-carboxy-4-oxocyclohexa-2,5-dienylidenemethylene)di(salicylic acid)
- ATA
- LABOTEST-BB LT00080677
- TIMTEC-BB SBB005410