2109805-75-4
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- CAS号:
- 2109805-75-4
- 英文名:
- CU-CPT17e
- 英文别名:
- CU-CPT17e;Toll-like Receptor (TLR),CU CPT17e,CUCPT17e,Inhibitor,CU-CPT17e,CU-CPT-17e,inhibit;Spiro[2H-1-benzopyran-2,4'-[4H]pyran], 2',3',5',6'-tetrahydro-6,7-bis[(4-nitrophenyl)methoxy]-
- 中文名:
- 2109805-75-4
- 中文别名:
- 化合物CU-CPT17E
- CBNumber:
- CB74634954
- 分子式:
- C27H24N2O8
- 分子量:
- 504.49
- MOL File:
- 2109805-75-4.mol
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2109805-75-4化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 5 mg/mL (9.91 mM)
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2109805-75-4性质、用途与生产工艺
CU-CPT17e 是一种有效的多 Toll 样受体 (TLR) 激动剂,可激活 TLR3,TLR8 和 TLR9。
CU-CPT17e shows strong NF-κB activation in TLR3, TLR8 and TLR9 HEK293 cells with EC
50
values of 4.80±0.73, 13.5±0.58 and 5.66±0.17 μM, respectively. CU-CPT17e significantly improves the activity with 13.9±0.9 fold of NF-κB activation and an EC
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value of 4.8±0.7 μM. CU-CPT17e inhibits the proliferation of HeLa cancer cells by triggering apoptosis and arresting the cell cycle at the S phase. The induction of apoptosis by CU-CPT17e in HeLa cells is investigated. HeLa cells are cultured with increasing concentrations of CU-CPT17e or poly I:C or blank control (DMSO) for 24 h. Treatment with CU-CPT17e for 24 h at different concentrations (10 to 40 μM) results in an elevation of apoptotic cell population ranging from 10% to 17%, which is more effective than poly I:C at 5 μg/mL. These results suggest that the antiproliferative activity of CU-CPT17e against HeLa cells might result from its ability to directly induce apoptosis.
2109805-75-4
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-101929 | 2109805-75-4 CU-CPT17e | 2109805-75-4 | 1mg | 2600元 |
2024/01/25 | HY-101929 | 2109805-75-4 CU-CPT17e | 2109805-75-4 | 5mg | 5400元 |
2109805-75-4, 2109805-75-4 相关搜索:
- 化合物CU-CPT17E
- 2109805-75-4
- Toll-like Receptor (TLR),CU CPT17e,CUCPT17e,Inhibitor,CU-CPT17e,CU-CPT-17e,inhibit
- Spiro[2H-1-benzopyran-2,4'-[4H]pyran], 2',3',5',6'-tetrahydro-6,7-bis[(4-nitrophenyl)methoxy]-
- CU-CPT17e