H-151
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- CAS号:
- 941987-60-6
- 英文名:
- 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
- 英文别名:
- H-151;H 151 NEW;H 151 (H-151);STING inhibitor;STING antagonist;H-151 (STING inhibitor);1-(4-Ethylphenyl)-3-(3-indolyl)urea;N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea;H151;H-151;H-151;H-151;STING ANTAGONIST;1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
- 中文名:
- H-151
- 中文别名:
- 化合物H-151;H 151,STING拮抗剂;1-(4-乙基苯基)-3-(3-吲哚基)脲;1-(4-乙基苯基)-3-(1H-吲哚-3-基)脲
- CBNumber:
- CB74635441
- 分子式:
- C17H17N3O
- 分子量:
- 279.34
- MOL File:
- 941987-60-6.mol
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H-151化学性质
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沸点:
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399.9±25.0 °C(Predicted)
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密度:
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1.298±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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Soluble in DMSO (25 mg/ml)
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形态:
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solid
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酸度系数(pKa):
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14.96±0.70(Predicted)
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颜色:
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Off-white
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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H-151性质、用途与生产工艺
H-151是STING的共价拮抗剂，在人细胞和体内均具有显著的抑制活性。
H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.
H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.
H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.
H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.
H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in
Trex1
−/−
mice that expressed a bioluminescent IFNβ reporter.
H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.
H-151
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-112693 | H-151
H-151 | 941987-60-6 | 5 mg | 800元 |
| 2024/01/25 | HY-112693 | H-151
H-151 | 941987-60-6 | 10mM * 1mLin DMSO | 880元 |
941987-60-6, H-151 相关搜索:
- 合成有机化合物配体
- 1-(4-乙基苯基)-3-(3-吲哚基)脲
- H 151,STING拮抗剂
- 化合物H-151
- 1-(4-乙基苯基)-3-(1H-吲哚-3-基)脲
- 941987-60-6
- 1-(4-Ethylphenyl)-3-(3-indolyl)urea
- H-151 (STING inhibitor)
- ERIS,phosphorylation,Stimulator of Interferon Genes,H-151,palmitoylatio,TMEM173,MPYS,inhibit,autoinflammatory,TBK1,STING,Inhibitor,MITA,H151,H 151
- H 151 (H-151)
- STING inhibitor
- Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-
- H 151 NEW
- H-151
- N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
- STING antagonist
- H151;H-151;H-151;H-151;STING ANTAGONIST
- 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea