KLH45
|
|
|
- CAS号:
- 1632236-44-2
- 英文名:
- KLH45
- 英文别名:
- KLH45;KLH45 >=98% (HPLC);N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide;2H-1,2,3-Triazole-2-carboxamide, N-cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-
- 中文名:
- KLH45
- 中文别名:
- 化合物KLH45;化合物 T24263
- CBNumber:
- CB74666104
- 分子式:
- C24H25F3N4O2
- 分子量:
- 458.48
- MOL File:
- 1632236-44-2.mol
|
|
|
KLH45化学性质
-
沸点:
-
561.0±60.0 °C(Predicted)
-
|
-
密度:
-
1.29±0.1 g/cm3(Predicted)
-
|
-
溶解度:
-
DMSO:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)-
|
-
酸度系数(pKa):
-
-1.76±0.20(Predicted)
-
|
KLH45性质、用途与生产工艺
KLH45 是有效、选择性的 DDHD2 抑制剂，其 IC50 值为 1.3 nM。
KLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.
KLH45 (2 μM) increases LD formation in fatty acid-supplemented DDHD2-expressing cells.
Cell Viability Assay
|
Cell Line:
|
COS-7 cells.
|
|
Concentration:
|
2 μM.
|
|
Incubation Time:
|
16 h.
|
|
Result:
|
Selectively blocked DDHD2 activity.
|
KLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2
−/−
mice.
|
Animal Model:
|
Mice.
|
|
Dosage:
|
5-40 mg/kg.
|
|
Administration:
|
IP, once.
|
|
Result:
|
Did not show altered brain TAGs.
|
KLH45
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-103060 | KLH45 | | 1 mg | 545元 |
| 2024/01/25 | HY-103060 | KLH45
KLH45 | 1632236-44-2 | 5mg | 1200元 |
1632236-44-2, KLH45 相关搜索:
- 化合物KLH45
- 化合物 T24263
- 1632236-44-2
- 2H-1,2,3-Triazole-2-carboxamide, N-cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-
- KLH45 >=98% (HPLC)
- N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide
- KLH45