2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇
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- CAS号:
- 212779-48-1
- 英文名:
- COMPOUND 52
- 英文别名:
- NG-52;NG-52, >98%;COMPOUND 52;NG 52 (Compound 52 );NG52; COMPOUND52;NG-52;COMPOUND-52;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE;2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE;2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol;2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-52
- 中文名:
- 2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇
- 中文别名:
- 化合物NG-52;CDC28P和PHO85P激酶抑制剂(NG 52);2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇;2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇, >98%
- CBNumber:
- CB7469930
- 分子式:
- C16H19ClN6O
- 分子量:
- 346.81
- MOL File:
- Mol file
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2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇化学性质
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沸点:
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587.7±60.0 °C(Predicted)
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密度:
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1.42±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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methylene chloride: 50 mg/mL, clear, colorless
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形态:
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powder
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酸度系数(pKa):
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14.54±0.10(Predicted)
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颜色:
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white to off-white
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2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇性质、用途与生产工艺
NG-52是三取代嘌呤，可结合酵母CDK的ATP结合区域，抑制Cdc28p和Pho85p，IC50分别为7 μM和2 μM。
| Target | Value |
Pho85p
(Cell-free assay)
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2 μM
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Cdc28p
(Cell-free assay)
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7 μM
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NG 52 (Compound 52) inhibits growth in a drug-sensitized yeast strain (
S. cerevisiae
) with a GI
50
of 30 μM. NG 52 is active against cdc2-cyclin B with an IC
50
value of 340 nM.
NG 52 dose-dependently inhibits the proliferation of glioma U87 and U251 cell lines with GI
50
values of 7.8 μM and 5.2 μM, respectively, meanwhile it potently inhibits the proliferation of primary glioma cells.
NG 52 (12.5-50 μM) effectively inhibits the phosphorylation of PDHK1 at Thr338 site and the phosphorylation of PDH at Ser293 site in U87 and U251 cells, resulting in more pyruvic acid entering the Krebs cycle with increased production of ATP and ROS.
NG 52 can reverse the Warburg effect by enhancing the activity of pyruvate dehydrogenase (PDH) through inhibiting the activity of PGK1, and switched cellular glucose metabolism from anaerobic mode to aerobic mode.
Cell Proliferation Assay
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Cell Line:
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Glioma U87 and U251 cells
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Concentration:
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0 μM, 12.5 μM, 25 μM, 50 μM
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Incubation Time:
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6 days
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Result:
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Potently inhibited the proliferation of primary glioma cells.
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Western Blot Analysis
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Cell Line:
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Glioma U87 and U251 cells
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Concentration:
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0 μM, 12.5 μM, 25 μM, 50 μM
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Incubation Time:
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12 hours or 24 hours
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Result:
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Potently inhibited the proliferation of primary glioma cells.
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NG 52 (50-150 mg/kg; oral administration; daily; for 13 days) treatment dose-dependently suppresses the growth of glioma xenograft.
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Animal Model:
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Female
nu/nu
mice (5-week-old) injected with glioma cells
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Dosage:
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50 mg/kg, 100 mg/kg, 150 mg/kg
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Administration:
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Oral administration; daily; for 13 days
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Result:
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Dose-dependently suppressed the growth of glioma xenograft.
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2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15154 | NG 52 | | 1 mg | 659元 |
| 2024/01/25 | HY-15154 | 2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇
NG 52 | 212779-48-1 | 5mg | 1451元 |
2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇
生产厂家
212779-48-1, 2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- Apoptosis and Cell Cycle
- Cell Biology
- Cell Signaling and Neuroscience
- Cell Cycle
- Cell Cycle Regulators
- BioChemical
- C16H19ClN6O
- 化合物NG-52
- CDC28P和PHO85P激酶抑制剂(NG 52)
- 2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇, >98%
- 2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇
- 212779-48-1
- cdc2-cyclin B,Cyclin dependent kinase,yeast,Pho85p,PGK1,CDK,Cdc28p,anti-proliferation,glioma,inhibit,Compound-52,ROS,ATP,Warburg,Compound52,CDK2,NG 52,ATP-compatible,PDHK1,Inhibitor
- Ethanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-
- NG-52, >98%
- NG52; COMPOUND52;NG-52;COMPOUND-52
- 2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
- NG 52 (Compound 52 )
- 2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]ethanol
- 2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol
- 2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-52
- COMPOUND 52
- 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
- 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE
- NG-52