CGS 15435
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- CAS号:
- 95853-92-2
- 英文名:
- CGS 15435
- 英文别名:
- CGS 15435;1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-
- 中文名:
- CGS 15435
- 中文别名:
- 化合物 T10783;化合物CGS 15435
- CBNumber:
- CB74797033
- 分子式:
- C20H21ClN2O2
- 分子量:
- 356.85
- MOL File:
- 95853-92-2.mol
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CGS 15435化学性质
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储存条件:
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Store at -20°C
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溶解度:
-
Soluble in DMSO
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CGS 15435性质、用途与生产工艺
CGS 15435 是一种有效的血栓烷 (TxA2) 合成酶抑制剂,IC50 为 1 nM, 比作用于环氧合酶,PGI2 合成酶和脂氧合酶的选择性高 100000 倍。
CGS 15435 is a highly specific Tx synthetase inhibitor. CGS 15435 is only weakly effective as an inhibitor of PGE
2
(Cyclooxygenase, IC
50
=1200 μM), prostacyclin (PGI
2
synthetase, IC
50
=90 μM) or 5-Lipoxygenase (IC
50
=60 μM) product formation.
CGS 15435 has a long duration of action, since the increases in the plasma levels of TxB
2
are prevented even at 24 h after CGS 15435 administration. CGS 15435 significantly inhibits TxB
2
formation 4, 6, 12 and 24 h after dosing. Administration of CGS 15435 0.25 or 24 h prior to Arachidonic acid (AA) produced no increase in TxB
2
in the surviving animals (4/4 and 5/6, respectively). The final TxB
2
levels in the CGS15435A (0.25 and 24 h pretreatment) groups are significantly lower (P<0.05) than those seen in the AA or the Dazoxiben (2 h pretreatment) groups.
CGS 15435
上下游产品信息
上游原料
下游产品
95853-92-2, CGS 15435 相关搜索:
- 化合物CGS 15435
- 化合物 T10783
- 95853-92-2
- 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-
- CGS 15435