PROTAC BET DEGRADER-2
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- CAS号:
- 2093388-33-9
- 英文名:
- PROTAC BET degrader-2
- 英文别名:
- PROTAC BET degrader-2;9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]propyl]-6-methoxy-
- 中文名:
- PROTAC BET DEGRADER-2
- 中文别名:
- CBNumber:
- CB74845048
- 分子式:
- C41H42N10O6
- 分子量:
- 770.84
- MOL File:
- 2093388-33-9.mol
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PROTAC BET DEGRADER-2化学性质
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密度:
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1.56±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 50 mg/mL (64.86 mM);Water : < 0.1 mg/mL (insoluble)
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酸度系数(pKa):
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10.73±0.40(Predicted)
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PROTAC BET DEGRADER-2性质、用途与生产工艺
PROTAC BET degrader-2 是一种强效的 溴域及末端外 (BET) 蛋白的降解剂，在 RS4;11 细胞中测得其对细胞生长的 IC50 值为 9.6 nM，并能实现肿瘤消退。
IC50: 9.6 nM (BET in the RS4;11 leukemia cell line).
PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC
50
value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.
PROTAC BET DEGRADER-2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-114228 | PROTAC BET degrader-2 | | 1 mg | 2181元 |
| 2024/01/25 | HY-114228 | PROTAC BET DEGRADER-2
PROTAC BET degrader-2 | 2093388-33-9 | 5mg | 4800元 |
PROTAC BET DEGRADER-2
生产厂家
2093388-33-9, PROTAC BET DEGRADER-2 相关搜索:
- C41H42N10O6
- 2093388-33-9
- 9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]propyl]-6-methoxy-
- PROTAC BET degrader-2