(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
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- CAS号:
- 150145-89-4
- 英文名:
- (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
- 英文别名:
- (S)-MCPG;(+)-MCPG;(+)-MCPG;(S)MCPG,(S) MCPG;(alphaS)-alpha-Amino-4-Carbo;(+)-α-methyl-4-carboxyphenylglycine;(S)-α-Methyl-4-carboxyphenylglycine;(S)-ALFA-METHYL-4-CARBOXYPHENYLGLYCINE;(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE;(+)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
- 中文名:
- (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
- 中文别名:
- 化合物 T13452;(+)-Α-甲基-4-羧基苯基甘氨酸;(S)-ALPHA-甲基-4-羧基苯甘氨酸;(+)-MCPG, 99.0+ % (HPLC);(ALPHAS)-ALPHA-氨基-4-羧基-ALPHA-甲基-苯乙酸;(+)-Α-METHYL-4-CARBOXYPHENYLGLYCINE
- CBNumber:
- CB7485802
- 分子式:
- C10H11NO4
- 分子量:
- 209.2
- MOL File:
- 150145-89-4.mol
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(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE化学性质
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沸点:
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425.3±40.0 °C(Predicted)
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密度:
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1.390±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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0.1 M NaOH: 15 mg/mL
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形态:
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solid
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酸度系数(pKa):
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1.76±0.10(Predicted)
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颜色:
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White to off-white
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旋光性 (optical activity):
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[α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.)
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(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE性质、用途与生产工艺
(S)-MCPG ((+)-MCPG) 是一种有效的 I/II 类代谢型谷氨酸受体 (mGluRs) 拮抗剂，是 (RS)-MCPG (HY-100371) 的活性异构体。(S)-MCPG 可用于 mGluRs 在空间学习中的作用研究。
(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures.
MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze.
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Animal Model:
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Male Lister-Hooded rats in the learning of the Morris water maze
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Dosage:
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20 μg
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Administration:
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Intraventricular injection; 20 μg; 4 days
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Result:
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Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
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(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-100406 | (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
(S)-MCPG | 150145-89-4 | 5mg | 800元 |
| 2024/01/25 | HY-100406 | (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
(S)-MCPG | 150145-89-4 | 10mg | 1100元 |
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
生产厂家
150145-89-4, (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE 相关搜索:
- Glutamate
- Glutamate receptor
- 化合物 T13452
- (+)-Α-甲基-4-羧基苯基甘氨酸
- (S)-ALPHA-甲基-4-羧基苯甘氨酸
- (+)-Α-METHYL-4-CARBOXYPHENYLGLYCINE
- (+)-MCPG, 99.0+ % (HPLC)
- (ALPHAS)-ALPHA-氨基-4-羧基-ALPHA-甲基-苯乙酸
- 150145-89-4
- (S)MCPG,(S) MCPG
- (+)-MCPG
- Benzeneacetic acid, α-amino-4-carboxy-α-methyl-, (αS)-
- Benzeneacetic acid, α-amino-4-carboxy-α-methyl-, (αS)-
- (alphaS)-alpha-Amino-4-Carboxy-alpha-Methyl-Benzeneacetic Acid
- (alphaS)-alpha-Amino-4-Carbo
- S(+)-α-Amino-4-carboxy-α-methyl-benzeneacetic acid
- (S)-α-Methyl-4-carboxyphenylglycine
- 4-[(1S)-1-Azaniumyl-1-Methyl-2-Oxido-2-Oxo-Ethyl]Benzoate
- 4-[(1S)-1-Ammonio-2-Keto-1-Methyl-2-Oxido-Ethyl]Benzoate
- 4-[(1S)-1-Ammonio-1-Methyl-2-Oxido-2-Oxoethyl]Benzoate
- (+)-MCPG, LY367385, S(+)-α-Amino-4-carboxy-α-methyl-benzeneacetic acid
- (+)-α-methyl-4-carboxyphenylglycine
- (+-)-A-METHYL-4-CARBOXYPHENYLGLYCINE GLU TAMATE RECEPTOR AN
- (+)-MCPG
- (S)-alpha-Methyl-4-carboxyphenylglycine(S)-MCPG
- (S)-ALFA-METHYL-4-CARBOXYPHENYLGLYCINE
- (+)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
- 4-((1S)-1-AMINO-1-CARBOXYETHYL)BENZOIC ACID
- (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
- S(+)-ALPHA-AMINO-4-CARBOXY-ALPHA-METHYL-BENZENEACETIC ACID
- (S)-MCPG