化合物NAE-IN-M22
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- CAS号:
- 864420-54-2
- 英文名:
- NEDD8 inhibitor M22
- 英文别名:
- NAE-IN-M22;NEDD8 inhibitor M22;4-Piperidinamine, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-;NAEINM22,cancer,Inhibitor,NAE-IN-M-22,NAE,NEDD8,NAE IN M22,enzyme,activating,inhibit,tumor,Apoptosis
- 中文名:
- 化合物NAE-IN-M22
- 中文别名:
- NEDD8抑制剂M22;化合物NAE-IN-M22
- CBNumber:
- CB75867548
- 分子式:
- C20H24Cl2N2
- 分子量:
- 363.32
- MOL File:
- 864420-54-2.mol
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化合物NAE-IN-M22化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (688.10 mM)
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化合物NAE-IN-M22性质、用途与生产工艺
NAE-IN-M22 是一种有效，选择性和可逆的 NEDD8 活化酶 (NAE) 抑制剂，效力在微摩尔范围内。NAE-IN-M22 抑制多种癌细胞生长并诱导 A549 细胞凋亡。NAE-IN-M22 还可以在体内抑制肿瘤的生长。
NEDD8 activating enzyme (NAE)
M22 (0.37-90 μM; 24 h) blocks neddylation pathway selectively and suppresses degradation of CRL substrates in A549 cells.
M22 (0.1-100 μM; 48 h) inhibits A549 cell proliferation completely at 30 µM (GI
50
=5.5 µM, GI
90
=19.3 µM).
M22 (15-30 μM; 36 h) promotes apoptosis in A549 cell line.
Cell Viability Assay
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Cell Line:
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A549 cells
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Concentration:
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0.37, 1.11, 3.33, 10, 30, 90 μM
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Incubation Time:
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24 hours
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Result:
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Inhibited formations of Uba3-NEDD8 and Ubc12-NEDD8.
Resulted in a corresponding decrease in the abundance of Cullins-NEDD8.
Decreased the degradations of p27 and CDT1.
Prevented p53 from degradation.
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M22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts.
M22 (0.36-90 μM) has low acute toxicity in zebrafish model.
化合物NAE-IN-M22
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-115537 | NAE-IN-M22 | | 1 mg | 960元 |
| 2024/04/30 | HY-115537 | 化合物NAE-IN-M22
NAE-IN-M22 | 864420-54-2 | 5mg | 2400元 |
864420-54-2, 化合物NAE-IN-M22 相关搜索:
- 药靶配体
- NEDD8抑制剂M22
- 化合物NAE-IN-M22
- 864420-54-2
- NAEINM22,cancer,Inhibitor,NAE-IN-M-22,NAE,NEDD8,NAE IN M22,enzyme,activating,inhibit,tumor,Apoptosis
- NAE-IN-M22
- 4-Piperidinamine, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-
- NEDD8 inhibitor M22