SHU-9119
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- CAS号:
- 168482-23-3
- 英文名:
- SHU-9119
- 英文别名:
- SHU-9119;SHU9119,TFA;CHEMBL3422426;SHU9119 (trifluoroacetate salt);AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2;AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG;AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2;Ac-Nle-cyclo(-Asp-His-D-2-Nal-Arg-Trp-Lys-NH2);AC-NLE4-C[ASP5, D-NAL(2)7, LYS10]ALPHA-MSH (4-10)-NH2;AC-NLE-CYCLO[(BETA-D)-H-(D-2-NAL)-RW-(EPSILON-K)]-NH2
- 中文名:
- SHU-9119
- 中文别名:
- 拮抗剂多肽SHU 9119;SHU-9119;CHEMBL3422426;AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2(CHEMICAL BRIDGE ASP2-LYS7);(3R,6R,9S,12R,15R,23R)-12-((1H-咪唑-5-基)甲基)-3-((1H-吲哚-3-基)甲基)-15-((R)-2-乙酰氨基己酰氨基)-6-(3-胍基丙基)-9-(萘-2-基甲基)-2,5,8,11,14,17-六氧代-1,4,7,10,13,18-六氮杂环二十三烷-23-甲酰胺
- CBNumber:
- CB7675726
- 分子式:
- C54H71N15O9
- 分子量:
- 1074.24
- MOL File:
- 168482-23-3.mol
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SHU-9119化学性质
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密度:
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1.43±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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H2O : 20 mg/mL (18.62 mM; Need ultrasonic)
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形态:
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Powder
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酸度系数(pKa):
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13.00±0.70(Predicted)
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颜色:
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White to off-white
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水溶解性:
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Soluble to 0.20 mg/ml in water
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序列:
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Ac-Nle-Asp-His-D-Nal-Arg-Trp-Lys-NH2(Chemical Bridge Asp2-Lys7)
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SHU-9119性质、用途与生产工艺
SHU 9119 是有效地人类黑皮素受体 3 和 4 (MC3/4R) 拮抗剂,同时也是 MC5R 的部分激动剂,对人类 MC3R, MC4R 和 MC5R 的 IC50 值分别为 0.23, 0.06 和 0.09 nM。
IC50: 0.23 nM (MC3R); 0.23 nM (MC4R); 0.23 nM (MC5R)
Blockade of CNS-Mcr via chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) increases food intake in ad libitum-fed rats compared with control. Weight gain of SHU9119 treated rats is significantly higher than control. SHU9119 treatment potently increases metabolic efficiency. SHU9119 markedly increases mRNA levels of genes promoting lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase. SHU9119 increases food intake (+30%) and body fat (+50%) and decreases EE by reduction in fat oxidation (−42%). In addition, SHU9119 impairs the uptake of VLDL-TG by BAT. In line with this, SHU9119 decreases uncoupling protein-1 levels in BAT (−60%) and induces large intracellular lipid droplets, indicative of severely disturbed BAT activity.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
SHU-9119
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-P0227 | SHU-9119 SHU 9119 | 168482-23-3 | 1mg | 1100元 |
2024/08/19 | HY-P0227 | SHU-9119 SHU 9119 | 168482-23-3 | 5mg | 4400元 |
168482-23-3, SHU-9119 相关搜索:
- 多肽合成
- 多肽
- 目录肽
- 标准品
- C54H71N15O9
- (3R,6R,9S,12R,15R,23R)-12-((1H-咪唑-5-基)甲基)-3-((1H-吲哚-3-基)甲基)-15-((R)-2-乙酰氨基己酰氨基)-6-(3-胍基丙基)-9-(萘-2-基甲基)-2,5,8,11,14,17-六氧代-1,4,7,10,13,18-六氮杂环二十三烷-23-甲酰胺
- 拮抗剂多肽SHU 9119
- SHU-9119;CHEMBL3422426
- AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2(CHEMICAL BRIDGE ASP2-LYS7)
- 168482-23-3
- (3R,6R,9S,12R,15R,23R)-12-((1H-Imidazol-5-yl)methyl)-3-((1H-indol-3-yl)methyl)-15-((R)-2-acetamidohexanamido)-6-(3-guanidinopropyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide
- SHU9119,TFA
- Acetyl-(Nle?,Asp?,D-2-Nal?,Lys??)-cyclo-α-MSH (4-10) amide trifluoroacetate salt
- Acetyl-(Nle?,Asp?,D-2-Nal?,Lys1?)-cyclo-α-MSH (4-10) amide trifluoroacetate salt
- Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide, SHU9119
- Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide
- CHEMBL3422426
- Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide trifluoroacetate salt
- L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam
- SHU9119 (trifluoroacetate salt)
- Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-Alpha-MSH (4-10) amide
- Ac-Nle-cyclo(-Asp-His-D-2-Nal-Arg-Trp-Lys-NH2)
- Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-a-MSH (4-10) aMide
- Ac-Nle-Asp-His-D-Nal(2)-Arg-Trp-Lys-NH2 (AMide bond Asp5-Lys10)
- Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) aMide
SHU9119
- Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10
- (Ac-Nle4,Asp5,D-Ala(2-naphthyl)7,Lys10)-cyclo-a-MSH (4-10) amide
- (ACETYL-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE TRIFLUOROACETATE SALT
- [ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MSH (4-10) AMIDE
- [ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MELANOCYTE STIMULATING HORMONE (4-10) AMIDE
- AC-NLE-CYCLO(-BETA-ASP-HIS-D-ALA(2-NAPHTHYL)-ARG-TRP-EPSILON-LYS-NH2)
- AC-NLE-CYCLO(BETA-ASP-HIS-D-2-NAL-ARG-TRP-EPSILON-LYS)-NH2
- AC-NLE-CYCLO[(BETA-D)-H-(D-2-NAL)-RW-(EPSILON-K)]-NH2
- AC-NLE-CYCLO(-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2) TRIFLUOROACETATE SALT
- AC-NLE4-C[ASP5, D-NAL(2)7, LYS10]ALPHA-MSH (4-10)-NH2
- (AC-NLE4,ASP5,D-ALA(2-NAPHTHYL)7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
- AC-[NLE4, ASP5, D-2-NAL7, LYS10]-CYCLO-ALPHA-MSH AMIDE (4-10)
- (AC-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
- AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2
- AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG
- AC-NLE-ASP-HIS-D-2'-NAL-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM
- AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2
- [N-ACETYL-NLE4,ASP5,D-2'-NAL7,LYS10]-ALPHA-MSH (4-10) AMIDE, ASP5-LYS10, CYCLIC LACTAM
- SHU-9119