CHPG
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- CAS号:
- 170846-74-9
- 英文名:
- CHPG
- 英文别名:
- CHPG;(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE;α-amino-2-chloro-5-hydroxybenzeneacetic acid;Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-;(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid;α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine
- 中文名:
- CHPG
- 中文别名:
- 化合物 T10809;(R,S)-CHPG,MGLU 5激动剂
- CBNumber:
- CB7723281
- 分子式:
- C8H8ClNO3
- 分子量:
- 201.61
- MOL File:
- 170846-74-9.mol
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CHPG化学性质
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沸点:
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407.3±45.0 °C(Predicted)
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密度:
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1.531±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥10mg/mL
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形态:
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solid &_& white solid
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酸度系数(pKa):
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1.61±0.10(Predicted)
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颜色:
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white
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CHPG性质、用途与生产工艺
CHPG 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。
CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO
2
derivatives treatment.
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO
2
-induced apoptosis.
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
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Cell Line:
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BV2 microglial cells
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Concentration:
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10, 50, 100 and 500 µM
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Incubation Time:
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24 hours
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Result:
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Increased the cell viability.
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Apoptosis Analysis
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Cell Line:
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BV2 microglial cells
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Concentration:
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0.5 mM
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Incubation Time:
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30 mins
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Result:
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Protected BV2 cells against SO
2
-induced apoptosis.
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Western Blot Analysis
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Cell Line:
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BV2 microglial cells
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Concentration:
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0.5 mM
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Incubation Time:
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30 mins
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Result:
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Increased the expression of TSG-6 in both mRNA and protein levels.
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CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
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Animal Model:
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Adult Sprague-Dawley male rats weighing 280-320 g
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Dosage:
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250 nM
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Administration:
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Injection; for 7 days
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Result:
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Reduced significantly cerebral lesion volume.
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CHPG
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101364 | CHPG | | 1 mg | 1636元 |
| 2024/04/30 | HY-101364 | CHPG
CHPG | 170846-74-9 | 5mg | 3600元 |
CHPG
生产厂家
全球有 37家供应商
CHPG国内生产厂家
170846-74-9, CHPG 相关搜索:
- Glutamate receptor
- 合成有机化合物配体
- (R,S)-CHPG,MGLU 5激动剂
- 化合物 T10809
- 170846-74-9
- Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-
- CHPG
- (RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE
- α-amino-2-chloro-5-hydroxybenzeneacetic acid
- (RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid
- α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine