SC-514
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- CAS号:
- 354812-17-2
- 英文名:
- SC-514
- 英文别名:
- SC-514;CS-707;GK01140;GK-01140;GK 01140;SC-514, >=98%;SC-514;GK 01140;SC-514 USP/EP/BP;IKK-2 Inhibitor, SC-514;4-Amino-[2,3']bithiophenyl-5-carboxamide
- 中文名:
- SC-514
- 中文别名:
- IKK-2抑制剂;化合物SC-514;IKK-2抑制剂(SC-514);4-氨基-[2,3']联噻吩-5-甲酰胺;4-氨基-[2,3'-二噻吩]-5-甲酰胺
- CBNumber:
- CB7832024
- 分子式:
- C9H8N2OS2
- 分子量:
- 224.3
- MOL File:
- 354812-17-2.mol
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SC-514化学性质
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熔点:
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209-211°C
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沸点:
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399.2±42.0 °C(Predicted)
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密度:
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1.450±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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酸度系数(pKa):
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15.63±0.50(Predicted)
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形态:
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powder
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颜色:
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white to light brown
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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SC-514性质、用途与生产工艺
SC-514 (GK 01140)是一种口服有效的,ATP竞争性的IKK-2抑制剂,IC50为3-12 μM,抑制NF-κB依赖性的基因表达,不抑制其他IKK异构体或其他丝-苏氨酸和酪氨酸激酶。
Target | Value |
IKK2
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3 μM-12 μM
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CDK2/CyclinA
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61 μM
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AUR2
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71 μM
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PRAK
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75 μM
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MSK
()
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123 μM
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SC-514以相似的强度抑制天然的IKK复合物或重组人IKK-1/IKK-2异二聚体和IKK-2同源二聚体的活性。在的IL-1β诱导的类风湿性关节炎的滑膜成纤维细胞(RASFs)中,SC-514抑制NF-κB依赖性的IL-6,IL-8,COX-2基因表达,IC50分别为20 μM,20 μM和8 μM。在RASFs中,100μM的SC-514抑制IκBα的磷酸化和降解,也降低p65转移到细胞核中的量。
在急性模型中,SC-514有效抑制LPS诱导的血清TNF-α生成。SC-514(50毫克/公斤,腹腔注射)抑制达70%TNF-α生产。
用途
A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12
μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown
to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.
SC-514
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-13802 | SC-514 | | 5 mg | 305元 |
2024/01/25 | HY-13802 | SC-514 SC-514 | 354812-17-2 | 10mM * 1mLin DMSO | 335元 |
354812-17-2, SC-514 相关搜索:
- Inhibitors
- All Inhibitors
- Apis
- IκB/IKK
- NF-kB
- 药靶配体
- 细胞生物学试剂
- 小分子抑制剂
- 小分子抑制剂,天然产物
- 芳烃衍生物
- 4-氨基-[2,3'-二噻吩]-5-甲酰胺
- 化合物SC-514
- IKK-2抑制剂(SC-514)
- IKK-2抑制剂
- 4-氨基-[2,3']联噻吩-5-甲酰胺
- 354812-17-2
- IKK,I kappa B kinase,GK-01140,SC-514,GK01140,IκB kinase,Inhibitor,SC514,SC 514,inhibit
- SC-514 USP/EP/BP
- CS-707
- GK 01140; SC 514; SC514; GK-01140; GK01140
- IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem
- 4-Amino-[2,3"]bithiophenyl-5-carboxylic acid amide
- 4-Amino-[2,3']bithiophenyl-5-carboxamide GK 01140
- [2,3'-Bithiophene]-5-carboxamide, 4-amino-
- 4-Amino-[2,3']bithiophenyl-5-carboxamide
- GK-01140
- GK01140
- GK 01140
- 5-(Thien-3-yl)-3-aminothiophene-2-carboxamide
- SC-514
- 4-Amino-[2',3'-bithiophene]-5-carboxamide
- IKK-2 Inhibitor, SC-514
- SC-514;GK 01140
- 3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide
- SC-514, >=98%