SC-514
|
|
|
- CAS号:
- 354812-17-2
- 英文名:
- SC-514
- 英文别名:
- SC-514;CS-707;GK01140;GK-01140;GK 01140;SC-514, >=98%;SC-514;GK 01140;SC-514 USP/EP/BP;IKK-2 Inhibitor, SC-514;4-Amino-[2,3']bithiophenyl-5-carboxamide
- 中文名:
- SC-514
- 中文别名:
- IKK-2抑制剂;化合物SC-514;IKK-2抑制剂(SC-514);4-氨基-[2,3']联噻吩-5-甲酰胺;4-氨基-[2,3'-二噻吩]-5-甲酰胺
- CBNumber:
- CB7832024
- 分子式:
- C9H8N2OS2
- 分子量:
- 224.3
- MOL File:
- 354812-17-2.mol
|
|
|
SC-514化学性质
-
熔点:
-
209-211°C
-
|
-
沸点:
-
399.2±42.0 °C(Predicted)
-
|
-
密度:
-
1.450±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Keep in dark place,Inert atmosphere,2-8°C
-
|
-
溶解度:
-
DMSO: soluble10mg/mL, clear
-
|
-
酸度系数(pKa):
-
15.63±0.50(Predicted)
-
|
-
形态:
-
powder
-
|
-
颜色:
-
white to light brown
-
|
-
稳定性:
-
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
-
|
SC-514性质、用途与生产工艺
SC-514 (GK 01140)是一种口服有效的，ATP竞争性的IKK-2抑制剂，IC50为3-12 μM，抑制NF-κB依赖性的基因表达，不抑制其他IKK异构体或其他丝-苏氨酸和酪氨酸激酶。
| Target | Value |
|
IKK2
|
3 μM-12 μM
|
|
CDK2/CyclinA
|
61 μM
|
|
AUR2
|
71 μM
|
|
PRAK
|
75 μM
|
MSK
()
|
123 μM
|
SC-514以相似的强度抑制天然的IKK复合物或重组人IKK-1/IKK-2异二聚体和IKK-2同源二聚体的活性。在的IL-1β诱导的类风湿性关节炎的滑膜成纤维细胞（RASFs）中，SC-514抑制NF-κB依赖性的IL-6，IL-8，COX-2基因表达，IC50分别为20 μM，20 μM和8 μM。在RASFs中，100μM的SC-514抑制IκBα的磷酸化和降解，也降低p65转移到细胞核中的量。
在急性模型中，SC-514有效抑制LPS诱导的血清TNF-α生成。SC-514（50毫克/公斤，腹腔注射）抑制达70%TNF-α生产。
用途
A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12
μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown
to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.
SC-514
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-13802 | SC-514 | | 5 mg | 305元 |
| 2024/01/25 | HY-13802 | SC-514
SC-514 | 354812-17-2 | 10mM * 1mLin DMSO | 335元 |
354812-17-2, SC-514 相关搜索:
- Inhibitors
- All Inhibitors
- Apis
- IκB/IKK
- NF-kB
- 药靶配体
- 细胞生物学试剂
- 小分子抑制剂
- 小分子抑制剂，天然产物
- 芳烃衍生物
- 4-氨基-[2,3'-二噻吩]-5-甲酰胺
- 化合物SC-514
- IKK-2抑制剂(SC-514)
- IKK-2抑制剂
- 4-氨基-[2,3']联噻吩-5-甲酰胺
- 354812-17-2
- IKK,I kappa B kinase,GK-01140,SC-514,GK01140,IκB kinase,Inhibitor,SC514,SC 514,inhibit
- SC-514 USP/EP/BP
- CS-707
- GK 01140; SC 514; SC514; GK-01140; GK01140
- IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem
- 4-Amino-[2,3"]bithiophenyl-5-carboxylic acid amide
- 4-Amino-[2,3']bithiophenyl-5-carboxamide GK 01140
- [2,3'-Bithiophene]-5-carboxamide, 4-amino-
- 4-Amino-[2,3']bithiophenyl-5-carboxamide
- GK-01140
- GK01140
- GK 01140
- 5-(Thien-3-yl)-3-aminothiophene-2-carboxamide
- SC-514
- 4-Amino-[2',3'-bithiophene]-5-carboxamide
- IKK-2 Inhibitor, SC-514
- SC-514;GK 01140
- 3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide
- SC-514, >=98%