呋塞米钠
|
|
- CAS号:
- 41733-55-5
- 英文名:
- sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
- 英文别名:
- Fursemide sodium;Frusemide Sodium;Sodium furosemide;FuroseMide (sodiuM);Sodium 5-(aminosulfonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate;sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate;5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid sodium salt
- 中文名:
- 呋塞米钠
- 中文别名:
- 速尿钠;呋塞米钠
- CBNumber:
- CB7886067
- 分子式:
- C12H12ClN2NaO5S
- 分子量:
- 354.74
- MOL File:
- 41733-55-5.mol
|
|
|
呋塞米钠化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: ≥ 150 mg/mL (425.25 mM)
-
|
呋塞米钠性质、用途与生产工艺
Furosemide sodium 是 Na+/K+/2Cl- (NKCC),NKCC1 和 NKCC2 共转运蛋白的有效的和具有口服活性抑制剂。Furosemide sodium 也是 GABAA 受体拮抗剂,对含 α6 受体的选择性是含 α1 受体的 100 倍。Furosemide sodium 用作利尿试剂,用于充血性心力衰竭,高血压和水肿的研究。
IC50: NKCC1 and NKCC2IC50: GABA
A
receptors
Furosemide sodium (500 µM; 72-96 hours) significantly changes the proliferation rates in MKN45 cells (the poorly differentiated human gastric adenocarcinoma cell line). however, it has no effects on MKN28 cells (the moderately differentiated human gastric adenocarcinoma cell line). The growth rate of MKN45 cells is larger than that of MKN28 cells.Furosemide sodium (10 µM, 30 µM, 100 µM; 45 min exposure)significantly decreases cation channel activity and [Ca(2+)](i) in human erythrocytes drawn from healthy individuals. Tert-butylhydroperoxide similarly enhances the non-selective cation channels activity, increases [Ca(2+)](i) and triggered cell membrane scrambling, however, the effects is significantly blunted by Furosemide sodium again.
Furosemide sodium (intraperitoneal injection; 100 mg/kg; single dose) is injected after kanamycin (KM) (1000 mg/kg) to creat a deaf mouse model in C57BL/6 mouse. After injection, hearing loss and cochlear hair cell damage are evaluated on day 1, day 2 and day 3, respectively. The hearing is markedly deteriorated even from the next day (Day-1 group), OHCs (outer hair cell) morphology of apical, middle and basal turns are disorganized in mice on day3.
呋塞米钠
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-B0135A | 呋塞米钠 Furosemide sodium | 41733-55-5 | 500mg | 900元 |
2024/04/30 | HY-B0135A | 呋塞米钠 Furosemide sodium | 41733-55-5 | 10mM * 1mLin DMSO | 990元 |
41733-55-5, 呋塞米钠 相关搜索:
- 药靶配体
- 速尿钠
- 呋塞米钠
- 41733-55-5
- Sodium furosemide
- Frusemide Sodium
- Sodium 5-(aminosulfonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
- FuroseMide (sodiuM)
- 5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid sodium salt
- Fursemide sodium
- sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate