网站主页 >> CAS数据库列表 >> calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate]
calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate]
|
|
|
- CAS号:
- 85068-56-0
- 英文名:
- calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate]
- 英文别名:
- Einecs 285-313-2;Proglumide hemicalcium;Calcium (1)-bis(4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate);calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate]
- 中文名:
- 中文别名:
- CBNumber:
- CB7940855
- 分子式:
- C36H50CaN4O8
- 分子量:
- 706.8822
- MOL File:
- 85068-56-0.mol
|
|
|
calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate]化学性质
calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate]性质、用途与生产工艺
Proglumide hemicalcium 是一种非肽和口服活性胆囊收缩素 (CCK)-A/B 受体拮抗剂。Proglumide hemicalcium 选择性阻断 CCK 在中枢神经系统中的作用。Proglumide hemicalcium 具有抑制胃分泌和保护胃十二指肠粘膜的能力，还具有抗癫痫和抗氧化活性。
Cholecystokinin (CCK)-A/B receptors
In an in vitro study, Proglumide at concentrations between 0.3-10 mM inhibits CCK-stimulated amylase release dose-dependently, while Proglumide does not influence the basal amylase release at concentrations between 0-3 mM. Dose-response curves to CCK for amylase release shifted to the right with increase in Proglumide concentration. This inhibition by Proglumide is reversible. In addition, the effect of Proglumide is selective for CCK and its related peptide.
The incubation of HT29 cells with Proglumide significantly reduces the [
3
H]-thymidine incorporation to HT29 cells in a dose-dependent manner, with an IC
50
of 6.5 mM. Proglumide reduces in a dose-dependent manner the percentage of necrosis with a parallel increase of apoptosis up to 70%.
Proglumide (250-750 mg/kg; intraperitoneal injection; adult male Sprague Dawley rats) treatment is significantly effective in ameliorating the seizure activities, cognitive dysfunctions, and cerebral oxidative stress.
|
Animal Model:
|
Adult male Sprague Dawley rats (200-250 g; 2 months old) are induced status epilepticus (SE)
|
|
Dosage:
|
250 mg/kg, 500 mg/kg, and 750 mg/kg
|
|
Administration:
|
Intraperitoneal injection
|
|
Result:
|
Dose-dependently and significantly increased the latencies to seizure and SE. Significantly and dose-dependently attenuated Li-PC (SE) induced increase in thiobarbituric acid (TBARS) and catalase (CAT), attenuated Li-Pc induced decrease in SOD, and attenuated depletion of GSH and glutathione-S transferase (GST) in the hippocampus and striatum.
|
calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate]
上下游产品信息
上游原料
下游产品
calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate]
生产厂家
85068-56-0, calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate] 相关搜索:
- 85068-56-0
- Proglumide hemicalcium
- Einecs 285-313-2
- Calcium (1)-bis(4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate)
- calcium (±)-bis[4-(benzoylamino)-5-(dipropylamino)-5-oxovalerate]