氨氟沙星
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- CAS号:
- 86393-37-5
- 英文名:
- amifloxacin
- 英文别名:
- AMFX;Win-49375;amifloxacin;amifloxacin USP/EP/BP;Inhibitor,Win-49375,Amifloxacin,inhibit,Win 49375,Bacterial;6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-3-quinolinecarboxylic acid;6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;6-Fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-
- 中文名:
- 氨氟沙星
- 中文别名:
- 氨氟沙星;氨氟哌酸;化合物 T17254;6-氟-1-(甲基氨基)-7-(4-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸
- CBNumber:
- CB7942460
- 分子式:
- C16H19FN4O3
- 分子量:
- 334.35
- MOL File:
- 86393-37-5.mol
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氨氟沙星化学性质
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熔点:
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300 °C (decomp)
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沸点:
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532.5±60.0 °C(Predicted)
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密度:
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1.44±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,Store in freezer, under -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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6.17±0.41(Predicted)
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颜色:
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White to light yellow
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氨氟沙星性质、用途与生产工艺
氨氟沙星与其他抗生素无交叉耐药性。化学结构上其特点是在喹啉环的6位上导入了氟,而7位都连有哌嗪基的衍生物,使本来亲脂性的吡酮类药物增加了适度的亲水性,降低了蛋白结合率,提高了生物利用度。抗菌谱比第一代及第二代喹诺酮类明显扩大,抗菌活性亦显著增强。
氨氟沙星为第三代喹诺酮类药物,抗菌作用机制为对细菌的DNA和 RNA合成均有显著的抑制作用。
Amifloxacin (Win49375) 是一种合成的喹诺酮类抗菌剂。
Amifloxacin (WIN 49375) is active in vitro against
Pseudomonas aeruginosa
isolates and shows moderate activity against
Staphylococcus aureus
, with MICs of less than or equal to 2 μg/mL.
Amifloxacin (WIN 49375) is highly active by the oral route, with 50% effective doses within two- to threefold of those obtained with parenteral medication. The effectiveness of Amifloxacin with various routes of medication is demonstrated with these experimental infections. When mice infected intraperitoneally with
E. coli
Vogel are medicated at 0.5-h postinfection subcutaneously, intravenously, or orally the ED
50
s for Amifloxacin are 0.6, 0.8, and 1.0 mg/kg, respectively. Blood radioactivity peaks at 0.5 h after oral administration of [
14
C]Amifloxacin mesylate to rats at 20 mg/kg and is equivalent to 7.1±0.26 μg of Amifloxacin per mL. From 0.75 to 4 h, blood radioactivity decreases rapidly from 7.0±0.25 μg/mL to 1.2±0.12 μg/mL. Between 8 and 48 h the rate of decline in blood radioactivity slows and is more complex. At 48 h, the blood radioactivity is equivalent to 0.14±0.02 μg/mL. Blood levels of radioactivity after i.v. administration of [
14
C]Amifloxacin mesylate to rats at 20 mg/kg decrease from 29.1±0.85 μg/mL at 1.0 min to 14.4±0.52 μg/mL at 10 min. From 0.25 to 4 h blood radioactivity decreases from 13.0±0.42 μg/mL to 0.97±0.09 μg/mL in a log-linear manner. The rate of elimination from 4 to 24 h is slower and more complex. At 24 h, blood radioactivity is equivalent to 0.12±0.01 ug/mL.
氨氟沙星
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-U00221 | 氨氟沙星 Amifloxacin | 86393-37-5 | 1mg | 1500元 |
2024/08/19 | HY-U00221 | 氨氟沙星 Amifloxacin | 86393-37-5 | 5mg | 3750元 |
86393-37-5, 氨氟沙星 相关搜索:
- 氨氟哌酸
- 化合物 T17254
- 6-氟-1-(甲基氨基)-7-(4-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸
- 氨氟沙星
- 86393-37-5
- 6-Fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- Inhibitor,Win-49375,Amifloxacin,inhibit,Win 49375,Bacterial
- amifloxacin USP/EP/BP
- 3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-
- amifloxacin
- Win-49375
- AMFX
- 6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-3-quinolinecarboxylic acid
- 6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid