丹酚酸B镁盐
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- CAS号:
- 122021-74-3
- 英文名:
- magnessium lithospermate B
- 英文别名:
- Magnesium Salvianolate B;magnessium lithospermate B;Monomethyl lithospermate B;MAGNESIUM LITHOSPERMATE B 98%;magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate
- 中文名:
- 丹酚酸B镁盐
- 中文别名:
- 丹參酸B鎂;丹参酚酸B甲酯;丹参酸 B 镁盐;丹参酚酸B甲酯对照品;丹参酚酸B甲酯标准品
- CBNumber:
- CB7980918
- 分子式:
- C36H28MgO16
- 分子量:
- 740.90292
- MOL File:
- 122021-74-3.mol
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丹酚酸B镁盐化学性质
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溶解度:
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Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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形态:
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Powder
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丹酚酸B镁盐性质、用途与生产工艺
Magnesium Lithospermate B 是从 Salviae miltiorrhizae 中提取的咖啡酸四聚体的衍生物。Magnesium Lithospermate B 被广泛用于心血管疾病的研究，并且可以防止葡萄糖引起的细胞内氧化损伤。Magnesium Lithospermate B 还能够抑制神经炎症并减轻神经变性。
Magnesium Lithospermate B (20-60 μg/ml; 24 h) decreases LDH activity in the cultured supernatant, increases SOD activity in cardiomyocytes, reduces intracellular ROS and MDA levels, and significantly suppresses cardiomyocytes apoptosis.
Magnesium Lithospermate B (1-100 μg/ml) enhances proliferation of neural stem cells (NSCs) in a dose-dependent manner.
Magnesium Lithospermate B (10 μg/ml) promotes the differentiation in vitro of NSCs towards neurons.
Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats.
Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models.
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Animal Model:
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Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats
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Dosage:
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2, 8 mg/kg
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Administration:
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P.o. once daily for 16 days
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Result:
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Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase.
Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21.
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丹酚酸B镁盐
上下游产品信息
上游原料
下游产品
122021-74-3, 丹酚酸B镁盐 相关搜索:
- standardized herbal extract
- reference standards from Chinese medicinal herbs (TCM).
- phytochemical
- pharmaceutical intermediate
- chemical reagent
- 丹参提取物
- 标准品-对照品
- 标准品 -中药标准品
- 标准品-中药标准品
- 标准品
- C36H28O16Mg
- C36H28MgO16
- 丹参酚酸B甲酯对照品
- 丹参酚酸B甲酯标准品
- 丹参酚酸B甲酯
- 丹参酸 B 镁盐
- 丹參酸B鎂
- 122021-74-3
- Magnesium Salvianolate B
- magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate
- magnessium lithospermate B
- Monomethyl lithospermate B
- MAGNESIUM LITHOSPERMATE B 98%