6-(4-硝基苄硫醇)鸟苷
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- CAS号:
- 13153-27-0
- 英文名:
- NBTGR
- 英文别名:
- NBTG;NBTGR;6-(4-nitrobenzylthio)guanosine;S-(P-NITROBENZYL)-6-THIOGUANOSINE;S-(4-NITROBENZYL)-6-THIOGUANOSINE;S-(4-Nitrobenzyl)-6-thioguanosine,99%;Guanosine, 6-S-[(4-nitrophenyl)methyl]-6-thio-;2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine;2-AMINO-6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE;S-(4-NITROBENZYL)-6-THIOGUANOSINE (NBTG) POTENT ADENOSINE TRAN
- 中文名:
- 6-(4-硝基苄硫醇)鸟苷
- 中文别名:
- 化合物 T12191;6-(4-硝基苄硫醇)鸟苷
- CBNumber:
- CB8123552
- 分子式:
- C17H18N6O6S
- 分子量:
- 434.43
- MOL File:
- 13153-27-0.mol
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6-(4-硝基苄硫醇)鸟苷化学性质
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熔点:
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203-205 °C
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沸点:
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858.3±75.0 °C(Predicted)
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密度:
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1.3888 (rough estimate)
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折射率:
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1.7000 (estimate)
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储存条件:
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0-6°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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13.07±0.70(Predicted)
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形态:
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Solid
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颜色:
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Off-white to yellow
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6-(4-硝基苄硫醇)鸟苷性质、用途与生产工艺
NBTGR (p-Nitrobenzylthioguanosine)是核苷转运 (nucleoside transport) 的有效抑制剂;抑制腺苷摄取的 Ki 值为70 nM。
Ki: 70 nM (adenosine uptake)
A group of purine ribonucleosides with alkarylmercapto substituents at the purine 6-position are potent inhibitors of several aspects of nucleoside metabolism that involved the transfer of ribosyl groups. NBTGR is one of the compounds that inhibits nucleoside transport by human erythrocytes; initial rates of uridine uptake are reduced to zero upon exposure of cells to 1 μM NBTGR. The inhibitor is firmly bound because repeated washing cannot restore uridine transport capability to NBTGR-treated cells. NBTGR inhibits the influx of uridine, inosine, and cytidine, without inhibiting the uptake of the corresponding bases, or that of D-glucose or L-leucine. Uridine antagonizes the NBTGR inhibition of uidine transport in a concentration-dependent manner. NBTGR and related compounds appear to interact with the mechanism for the facilitated transport of nucleosides.
6-(4-硝基苄硫醇)鸟苷
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-108322 | 6-(4-硝基苄硫醇)鸟苷 NBTGR | 13153-27-0 | 1mg | 772元 |
2024/08/19 | HY-108322 | 6-(4-硝基苄硫醇)鸟苷 NBTGR | 13153-27-0 | 5mg | 1700元 |
13153-27-0, 6-(4-硝基苄硫醇)鸟苷 相关搜索:
- Specialty Synthesis
- Nucleosides
- Oligonucleotide Synthesis
- C17H18N6O6S
- 化合物 T12191
- 6-(4-硝基苄硫醇)鸟苷
- 13153-27-0
- Guanosine, 6-S-[(4-nitrophenyl)methyl]-6-thio-
- NBTG
- 2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
- S-(4-Nitrobenzyl)-6-thioguanosine,99%
- NBTG, NBTGR, 2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
- S-(4-NITROBENZYL)-6-THIOGUANOSINE (NBTG) POTENT ADENOSINE TRAN
- 2-AMINO-6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE
- NBTGR
- S-(P-NITROBENZYL)-6-THIOGUANOSINE
- S-(4-NITROBENZYL)-6-THIOGUANOSINE
- 6-(4-nitrobenzylthio)guanosine