PBOX 6
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- CAS号:
- 290814-68-5
- 英文名:
- PBOX-6
- 英文别名:
- PBOX-6;PBOX-6 >=98% (HPLC);Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7-yl ester
- 中文名:
- PBOX 6
- 中文别名:
- 化合物 T16436
- CBNumber:
- CB81361023
- 分子式:
- C25H20N2O3
- 分子量:
- 396.44
- MOL File:
- 290814-68-5.mol
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PBOX 6化学性质
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熔点:
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177-179 °C(Solv: ethanol (64-17-5))
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沸点:
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580.6±50.0 °C(Predicted)
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密度:
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1.22±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO
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形态:
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powder
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酸度系数(pKa):
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-1.32±0.70(Predicted)
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颜色:
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white to beige
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PBOX 6性质、用途与生产工艺
PBOX 6 是一种 pyrrolo-1,5-benzoxazepine (PBOX) 化合物,可作为微管解聚剂和促凋亡剂起作用。
PBOX 6 is a potent apoptotic PBOX, but does not elicit a general toxic effect in a rat R2C Leydig cell line. PBOX 6 (0-25 μM, 16 h) results in dose- and time-dependent induction of apoptosis, and also causes DNA fragmentation at 10 μM in HL-60 cells. PBOX 6 (10 μM) induces apoptosis through activation of caspase 3-like proteases in HL-60 cells. PBOX 6 (10 μM) induces apoptosis and exerts an accumulation of cytochromec in the cytosol, but this effect is not triggered by oxidative stress, and is independent of peripheral-type benzodiazepine receptor (PBR) and NF-κB. PBOX 6 (25 μM) induces apoptosis in MCF-7 cells through activation of caspase-7. PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells. PBOX 6 (10 μM) induces nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner, also dependent on upstream activation of a trypsin-like serine protease, and this effect correlates with G2/M arrest in K562 cells.
PBOX 6
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-U00446 | PBOX 6 PBOX 6 | 290814-68-5 | 5mg | 1600元 |
2024/04/30 | HY-U00446 | PBOX 6 | | 10 mM * 1 mLin DMSO | 1760元 |
290814-68-5, PBOX 6 相关搜索:
- 化合物 T16436
- 290814-68-5
- PBOX-6 >=98% (HPLC)
- Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7-yl ester
- PBOX-6