S-2-羟基戊二酸
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- CAS号:
- 63512-50-5
- 英文名:
- L-A-HYDROXYGLUTARIC ACID DISODIUM)
- 英文别名:
- L-2-HG;SKL187;Disodium (S)-2-hydroxyglutarate;(S)-2-Hydroxypentanedioic acid;Sodium (S)-2-hydroxypentanedioate;L-2-Hydroxyglutarate DisodiuM Salt;L-α-Hydroxyglutaricaciddisodiumsal;L-2-Hydroxyglutaric acid (disodium);(S)-2-Hydroxyglutaric acid disodium;L-ALPHA-HYDROXYGLUTARIC ACID DISODIU
- 中文名:
- S-2-羟基戊二酸
- 中文别名:
- S-2-羟基戊二酸二钠;S-2-羟基戊二酸钠盐;L-Α-羟基戊二酸二钠盐;(S)-2-羟基戊二酸钠;L-Α-羟基戊二酸二钠盐;S-2-羟基戊二酸 二钠盐/S-2-羟基戊二酸二钠
- CBNumber:
- CB81473690
- 分子式:
- C5H9NaO5
- 分子量:
- 172.11
- MOL File:
- 63512-50-5.mol
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S-2-羟基戊二酸化学性质
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熔点:
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>300°C
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储存条件:
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2-8°C
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溶解度:
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Methanol (Very Slightly), Water (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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旋光性 (optical activity):
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[α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
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BRN:
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5318042
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S-2-羟基戊二酸性质、用途与生产工艺
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) 是一种表观遗传修饰剂和在肾脏癌中推测的肿瘤代谢物，抑制 histone demethylases，因此促进组蛋白甲基化。L-2-Hydroxyglutaric acid disodium 也是一种 mitochondrial creatine kinase (Mi-CK) 的抑制剂，对应的Km值和Ki值分别为2.52 mM和11.13 mM。
| Target | Value |
Histone Demethylase
()
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Mi-CK
(Cell-free assay)
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2.52 mM(Km)
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Mi-CK
(Cell-free assay)
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11.13 mM(Ki)
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L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes.
S-2-羟基戊二酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-W015114 | L-2-Hydroxyglutaric acid disodium | | 5 mg | 343元 |
| 2024/01/25 | HY-W015114 | S-2-羟基戊二酸
L-2-Hydroxyglutaric acid disodium | 63512-50-5 | 10mg | 550元 |
63512-50-5, S-2-羟基戊二酸 相关搜索:
- Chiral Reagents
- Aliphatics
- Inhibitors
- 药靶配体
- 合成
- C5H8Na2O5
- C5H6O5Na2
- L-Α-羟基戊二酸二钠盐
- (S)-2-羟基戊二酸钠
- L-Α-羟基戊二酸二钠盐
- S-2-羟基戊二酸钠盐
- S-2-羟基戊二酸 二钠盐/S-2-羟基戊二酸二钠
- S-2-羟基戊二酸二钠
- 63512-50-5
- L-α-Hydroxyglutaric Acid (sodium salt)
- L 2 Hydroxyglutaric acid disodium,modifier,demethylases,methylation,Mitochondrial Metabolism,Histone Demethylase,Inhibitor,renal,cancer,epigenetic,inhibit,histone,L2Hydroxyglutaric acid disodium
- L-α-Hydroxyglutaricaciddisodiumsal
- SKL187
- L-α-Hydroxyglutaric acid disodium salt
- Pentanedioic acid, 2-?hydroxy-?, sodium salt (1:2)?, (2S)?-
- (S)-2-Hydroxyglutaric acid disodium
- L-2-HG
- L-a-Hydroxyglutaric acid disodium salt
- Sodium (S)-2-hydroxypentanedioate
- L-α-Hydroxyglutaric Acid (sodium salt)
- L-2-Hydroxyglutaric acid (disodium)
- L-alpha-hydroxyglutaric acid, disodium salt
- L-2-Hydroxyglutarate DisodiuM Salt
- (S)-α-Hydroxyglutaric Acid DisodiuM Salt
- L-ALPHA-HYDROXYGLUTARIC ACID DISODIU
- Disodium (S)-2-hydroxyglutarate
- Pentanedioic acid, 2-hydroxy-, sodiuM salt (1:2)
- s-2-Hydroxypentanedioic acid disodium salt
- Pentanedioic acid,2-hydroxy-, disodium salt, (2S)-
- (2S)-2-Hydroxyglutaric Acid Disodium Salt
- L-α-Hydroxyglutaric acid disodium salt
- (S)-2-Hydroxypentanedioic acid