唑喹达三盐酸盐

唑喹达三盐酸盐性质、用途与生产工艺

生物活性

Zosuquidar 3HCl (LY335979, RS 33295-198, D06387) 是一种有效的P-glycoprotein介导的多药耐抗性的调节剂，无细胞试验中Ki为60 nM。Phase 3。

靶点

Target	Value
P-gp (Cell-free assay)	60 nM(Ki)

体外研究

LY335979 竞争性抑制[LY335979作用于表达P-gp的白血病细胞系，包括K562/HHT40, K562/HHT90, K562/DOX 和 HL60/DNR，显著恢复药物敏感性，且作用于携带活性P-gp的原发性AML细胞，增强蒽环类药物(Daunorubicin, Idarubicin, Mitoxantrone)和gemtuzumab ozogamicin 的毒性。 最新文献说明LY335979作用于ABCB1转导的细胞，完全抑制(Z)-endoxifen在顶端调控的运输。

体内研究

唑喹达三盐酸盐 上下游产品信息

上游原料

下游产品

唑喹达三盐酸盐 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/01/25	HY-50671	Zosuquidar trihydrochloride		1 mg	477元
2024/01/25	HY-50671	唑喹达三盐酸盐 Zosuquidar trihydrochloride	167465-36-3	5mg	1050元

唑喹达三盐酸盐 生产厂家

 

167465-36-3, 唑喹达三盐酸盐 相关搜索:

• Pharmaceuticals
• Intermediates & Fine Chemicals
• Heterocycles
• Chiral Reagents
• Aromatics
• Inhibitors
• 药靶配体
• 细胞生物学试剂
• 小分子抑制剂，天然产物
• 膜转运
• 离子通道
• 膜转运/离子通道
• 信号转导通路激酶抑制剂
• C32H31F2N3O23ClH
• C32H34Cl3F2N3O2
• C32H31F2N3O23HCl
• ZOSUQUIDAR 3HCL;LY335979
• (R)-1-(4-((1AR,6R,10BS)-1,1-二氟-1,1A,6,10B-四氢二苯并[A,E]环丙烷[C][7]轮烯-6-基)哌嗪-1-基)-3-(喹啉-5-基氧基)丙-2-醇三盐酸盐
• LY 335979; LY-335979; LY335979; D06387; RS33295198; ZOSUQUIDAR HCL; ZOSUQUIDAR 3HCL; ZOSUQUIDAR TRIHYDROCHLORIDE
• 化合物ZOSUQUIDAR 3HCL
• P-糖蛋白抑制剂(唑喹达三盐酸盐)
• ZOSUQUIDAR 三盐酸盐
• 唑喹达三盐酸盐
• 唑喹达盐酸盐
• (2R)-1-{4-[(1AR,6R,10BS)-1,1-二氟-1,1A,6,10B-四氢二苯并[A,E]环丙并[C]环庚烯-6-基]哌嗪-1-基}-3-(喹啉-5-基氧基)丙-2-醇三盐酸盐
• 167465-36-3
• Levodropropizine Impurity 12
• 1-(3-aminocyclopentyl)-N,N-dimethyl-pyrrolidin-3-amine
• 4-piperazin-1-ylpyrrolidin-2-one
• LY335979(Zosuquidar)/Zosuquidar trihydrochloride, RS-33295-198
• CEM/VLB100,Pgp,2780AD,Multidrug resistance protein 1,CD243,anti-tumor activity,P388/ADR,P-glycoprotein,UCLA-P3.003VLB,2780,ABCB1,MCF7,acute myelogenous leukemia,MDR1,HL60,P-gp,UCLA-P3,P388,MCF7/ADR,CCRF-CEM,K562,Inhibitor,Zosuquidar trihydrochloride,Cluster of differentiation 243,AML,inhibit
• Zosuquidar trihydrochloride 3HCL
• Trihydrochloride
• LY335979
• Zosuquidar (LY335979) triHydrochloride
• D06387
• LY 335979; LY-335979; LY335979; D06387; RS33295198;
• (R)-1-(4-((1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl)piperazin-1-yl)-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride
• Zosuquidr.3HCl
• Zosuquidar HCl
• Zosuquidar (RS 33295-198
• LY335979) 3HCl
• 1-Piperazineethanol,4-[(1aa,6a,10ba)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-a-[(5-quinolinyloxy)methyl]-,hydrochloride (1:3), (aR)-
• ZOSUQUIDAR TRIHYSROCHLORIDE USP/EP/BP
• Zosuquidar TriHCl
• RS 33295-198 trihydrochloride
• LY-335979 trihydrochloride
• CS-58
• RS-33295-198; ZOSUQUIDAR; LY-335979
• (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride
• Zosuquidar (LY335979) 3HCl
• Zosuquidr.3HCl(LY335979)
• Zosuquidar trihydrochloride LY335979
• (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride Zosuquidar trihydrochloride LY335979
• RS 33295-198 (D06387) 3HCl
• 1-Piperazineethanol, 4-[(1aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-,trihydrochloride
• Zosuquidar (LY335979
• (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride