甲磺酸萘非那韦
|
|
|
- CAS号:
- 159989-64-7
- 英文名:
- NELFINAVIR
- 英文别名:
- AG 1341;nefinavir;NELFINAVIR;NELFINAVIR-12;Nelfinavir D5;8a-beta))-a-bet;NELFINAVIR iMpurity;NELFINAVIR USP/EP/BP;Nelfinavir (AG-1341);Nelfinavir Regeoisomer
- 中文名:
- 甲磺酸萘非那韦
- 中文别名:
- 奈非那韦;尼非那韦;娜芙维亚;萘非那韦;奈非那韦杂质;甲磺酸萘非那韦;化合物AZD7762;(3S,4AS,8AS)-N-(叔丁基)-2-((2R,3R)-2-羟基-3-(3-羟基-2-甲基苯甲酰胺基)-4-(苯硫基)丁基)十氢异喹啉-3-羧酰胺;2-[(2R,3R)-2-羟基-3-[(3-羟基-2-甲基苯甲酰)氨基]-4-(苯基硫)丁基]-(3S,4aS,8aS)-N-叔丁基十氢异喹啉-3-甲酰胺
- CBNumber:
- CB8213806
- 分子式:
- C32H45N3O4S
- 分子量:
- 567.78
- MOL File:
- 159989-64-7.mol
|
|
|
甲磺酸萘非那韦化学性质
-
熔点:
-
185-186 °C
-
|
-
沸点:
-
786.8±60.0 °C(Predicted)
-
|
-
比旋光度:
-
D -119.23° (c = 0.26 in methanol)
-
|
-
密度:
-
1.22±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
under inert gas (nitrogen or Argon) at 2–8 °C
-
|
-
溶解度:
-
≥ 20.45mg/mL in Ethanol
-
|
-
形态:
-
Powder
-
|
-
酸度系数(pKa):
-
pKa1 6.0; pKa2 11.06(at 25℃)
-
|
-
水溶解性:
-
7g/L(temperature not stated)
-
|
甲磺酸萘非那韦性质、用途与生产工艺
Nelfinavir (AG-1341) 是一种有效的口服生物可利用的 HIV-1 蛋白酶抑制剂 (Ki=2 nM) 用于 HIV 感染。Nelfinavir (AG-1341) 是一种广谱的抗癌剂。
Nelfinavir (AG1341) (1-10 μM; 48 hours) inhibits the proliferation of multiple myeloma cells.
Nelfinavir inhibits 26S chymotrypsin-like proteasome activity, impairs proliferation and triggers apoptosis of the myeloma cell lines and fresh plasma cells.
Nelfinavir (1-10 μM; 17 hours) induces apoptosis of multiple myeloma cell lines.
Nelfinavir (5 μM; 0-24 hours) decreases the phosphorylation of AKT.
Nelfinavir activates the cleavage of caspase-3, decreases the phosphorylation of AKT, STAT-3, ERK1/2, and activates the pro-apoptotic pathway of the unfolded protein response system.
Cell Proliferation Assay
|
Cell Line:
|
RPMI, LP1, U266, OPM2 and MM1S cells
|
|
Concentration:
|
1, 2, 5, 10 μM
|
|
Incubation Time:
|
48 hours
|
|
Result:
|
Inhibited the proliferation of RPMI, LP1, U266, OPM2 and MM1S cell lines in a dose-dependent manner with an IC
50
of 1-5 μM.
|
Apoptosis Analysis
|
Cell Line:
|
LP1 and U266 cells
|
|
Concentration:
|
1-10 μM
|
|
Incubation Time:
|
17 hours
|
|
Result:
|
Induced a dose-dependent increase in the percentage of annexin V
+
/propidium iodide
+
cells.
|
Western Blot Analysis
|
Cell Line:
|
U266 cells
|
|
Concentration:
|
5 μM
|
|
Incubation Time:
|
0-24 hours
|
|
Result:
|
The level of AKT phosphorylation in U266 cells decreased.
|
Nelfinavir (AG1341) (75 mg/kg; i.p.; 5 days a week for 21 days) decreases multiple myeloma cell growth in NOD/SCID mice.
|
Animal Model:
|
NOD/SCID mice (bearing U266-luc cells)
|
|
Dosage:
|
75 mg/kg
|
|
Administration:
|
I.p.; 5 days a week for 21 days
|
|
Result:
|
Decreased MM cell growth in NOD/SCID mice.
|
甲磺酸萘非那韦
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15287 | Nelfinavir | | 1 mg | 380元 |
| 2024/01/25 | HY-15287 | 甲磺酸萘非那韦
Nelfinavir | 159989-64-7 | 2mg | 600元 |
甲磺酸萘非那韦
生产厂家
全球有 101家供应商
甲磺酸萘非那韦国内生产厂家
159989-64-7, 甲磺酸萘非那韦 相关搜索:
- peptides
- 化学试剂
- C32H45N3O4SC32H45N3O4SCH3SO3H
- C32H45N3O4SCH4O3S
- 化合物AZD7762
- (3S,4AS,8AS)-N-(叔丁基)-2-((2R,3R)-2-羟基-3-(3-羟基-2-甲基苯甲酰胺基)-4-(苯硫基)丁基)十氢异喹啉-3-羧酰胺
- 萘非那韦
- 奈非那韦杂质
- 2-[(2R,3R)-2-羟基-3-[(3-羟基-2-甲基苯甲酰)氨基]-4-(苯基硫)丁基]-(3S,4aS,8aS)-N-叔丁基十氢异喹啉-3-甲酰胺
- 奈非那韦
- 尼非那韦
- 娜芙维亚
- 甲磺酸萘非那韦
- 159989-64-7
- NELFINAVIR iMpurity
- Nelfinavir D5
- Nelfinavir (AG-1341)
- (3S,4aS,8aS)-N-(tert-Butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide
- NELFINAVIR USP/EP/BP
- 3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-
- AG 1341; AG-1341; AG1341
- N-tert-butyl-2-[2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)-oxomethyl]amino]-4-(phenylthio)butyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
- Nelfinavir Regeoisomer
- NELFINAVIR-12
- AG 1341
- Nelfinavir & Nelfinavir Mesylate
- (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide
- NELFINAVIR
- nefinavir
- 8a-beta))-a-bet
- 3-isoquinolinecarboxamide,n-(1,1-dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hy