蛋白磷酸酯酶抑制剂
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- CAS号:
- 101932-71-2
- 英文名:
- CALYCULIN A
- 英文别名:
- C05370;CALYCULIN A;(-)-CALYCULIN A;Calyculin A
((-)-Calyculin A);CALYCULIN A, DISCODERMIA CALYX;calyculin A from discodermia calyx;CALYCULIN A FROM DISCODERMIA CALYX, 10 U G;Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem;InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem;N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam
- 中文名:
- 蛋白磷酸酯酶抑制剂
- 中文别名:
- 花萼海绵诱癌素;花萼海绵体诱癌素A;蛋白磷酸酯酶抑制剂;PP2A催化亚基抑制剂(CALYCULIN A)
- CBNumber:
- CB8233130
- 分子式:
- C50H81N4O15P
- 分子量:
- 1009.17
- MOL File:
- 101932-71-2.mol
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蛋白磷酸酯酶抑制剂化学性质
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熔点:
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247-249°
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比旋光度:
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D -60° (c = 0.1 in ethanol)
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密度:
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1.25±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble
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酸度系数(pKa):
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1.81±0.10(Predicted)
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形态:
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solid
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颜色:
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white
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旋光性 (optical activity):
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+59.815 (Ethanol)
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水溶解性:
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Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water.
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Merck:
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13,1731
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BRN:
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4903216
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蛋白磷酸酯酶抑制剂性质、用途与生产工艺
Calyculin A ((-)-Calyculin A) 是有效,可渗透细胞的蛋白磷酸酶 1 (PP1) 和蛋白磷酸酶 2A (PP2A) 抑制剂,其 IC50 值分别为 2 nM 和 0.5-1 nM。
IC50: 2 nM (PP1); 0.5-1 nM (PP2A)
Calyculin A (1-10 nM; 24 hours) induces cytotoxicity in MG63 cells in a dose-dependent manner up to 10 nM in MG63 cells.
Cell Cytotoxicity Assay
Cell Line:
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Human osteosarcoma MG63 cells
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Concentration:
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0, 1, 2, 5, 10 nM
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Incubation Time:
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24 hours
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Result:
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Treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures.
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蛋白磷酸酯酶抑制剂
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-18983 | 蛋白磷酸酯酶抑制剂 Calyculin A | | 5 μg (0.5 mM * 10 μL in DMSO) | 1600元 |
2024/08/19 | HY-18983 | 蛋白磷酸酯酶抑制剂 Calyculin A | 101932-71-2 | 10μg(0.5mM * 20μL in DMSO) | 2650元 |
101932-71-2, 蛋白磷酸酯酶抑制剂 相关搜索:
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- Cell Biology
- C50H81N4O15P
- 花萼海绵体诱癌素A
- 花萼海绵诱癌素
- PP2A催化亚基抑制剂(CALYCULIN A)
- 蛋白磷酸酯酶抑制剂
- 101932-71-2
- L-Ribonamide, N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraen-1-yl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propen-1-yl]-2-oxazolyl]butyl]-4-deoxy-4-(dimet...
- Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
- InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
- Calyculin A
((-)-Calyculin A)
- (-)-CALYCULIN A
- CALYCULIN A
- L-Ribonamide, N-(3S)-3-4-(1E)-3-(2R,3R,5R,7S,8S,9R)-2-(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro4.5dec-7-yl-1-propenyl-2-oxa
- N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-Methoxy-4,6,8,9,13-pentaMethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-triMethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-o
- N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam
- CALYCULIN A FROM DISCODERMIA CALYX, 10 U G
- calyculin A from discodermia calyx
- CALYCULIN A, DISCODERMIA CALYX
- N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide
- C05370