WAY-100635;WAY 100635; WAY100635
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- CAS号:
- 162760-96-5
- 英文名:
- CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)
- 英文别名:
- N-ethyl]piperazinyl]methoxyphenyl)WAY 100635;WAY100635;cyclohexanecarboxamiWAY100635 TRIHYDROCHLORIDE;WAY-100635;WAY 100635; WAY100635;Cyclohexanecarboxamide,N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-;N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxaMide
- 中文名:
- WAY-100635;WAY 100635; WAY100635
- 中文别名:
- 化合物 T21561;WAY-100635,5-HT1A受体拮抗剂;N-(2-(4-(2-甲氧基苯基)哌嗪-1-基)乙基)-N-(吡啶-2-基)环己甲酰胺
- CBNumber:
- CB82448237
- 分子式:
- C25H34N4O2
- 分子量:
- 422.56
- MOL File:
- 162760-96-5.mol
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WAY-100635;WAY 100635; WAY100635化学性质
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熔点:
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>145oC (dec.)
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沸点:
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594.8±50.0 °C(Predicted)
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密度:
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1.154±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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Methanol (Slightly), Water (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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6.84±0.10(Predicted)
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颜色:
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Off-White to Pale Yellow
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稳定性:
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Hygroscopic
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WAY-100635;WAY 100635; WAY100635性质、用途与生产工艺
WAY-100635 是一种有效且具有选择性的 5-hydroxytryptamine 1A (5-HT1A) 受体拮抗剂，其 IC50 值为 0.91 nM，Ki 值为 0.39 nM。WAY-100635 对于 5-HT1A 和 α1-肾上腺素的 pIC50 值分别为 8.9 和 6.6。WAY-100635 也是一种有效的多巴胺 D4 受体激动剂。
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5-HT
1A
Receptor
8.87 (pIC
50
)
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5-HT
1A
Receptor
9.71 (pA2)
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The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D
2L
or D
4.4
receptors.
WAY-100635 displays 940, 370, and 16 nM binding affinities at D
2L
, D
3
, and D
4.2
receptors, respectively. Saturation analyses demonstrat that the
K
d
of [
3
H] WAY-100635 at D
4.2
receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D
4.4
cells with
EC
50
of 9.7 nM. WAY-100635 possesses high affinity for D
4.4
receptor (3.3 nM) .
WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat.
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Animal Model:
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Male Sprague-Dawley rats (220-240 g)
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Dosage:
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1 mg/kg
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Administration:
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Subcutaneous injection (Pharmacokinetic study)
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Result:
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Reduced total abstinence score, increased immobility time and the burying behavior was increased.
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WAY-100635;WAY 100635; WAY100635
上下游产品信息
上游原料
下游产品
WAY-100635;WAY 100635; WAY100635
生产厂家
162760-96-5, WAY-100635;WAY 100635; WAY100635 相关搜索:
- 高端化学
- G蛋白偶联受体&G蛋白
- C25H34N4O2
- WAY-100635,5-HT1A受体拮抗剂
- 化合物 T21561
- N-(2-(4-(2-甲氧基苯基)哌嗪-1-基)乙基)-N-(吡啶-2-基)环己甲酰胺
- 162760-96-5
- piperazinyl]
- N-
- methoxyphenyl)
- ethyl]
- cyclohexanecarboxami
- WAY 100635;WAY100635
- N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxaMide
- WAY100635 TRIHYDROCHLORIDE
- WAY-100635;WAY 100635; WAY100635
- Cyclohexanecarboxamide,N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-
- CYCLOHEXANECARBOXYLIC ACID (2-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-ETHYL)-PYRIDIN-2-YL-AMIDE TRIHYDROCHLORIDE
- CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)