网站主页 >> CAS数据库列表 >> PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
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- CAS号:
- 113906-27-7
- 英文名:
- 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
- 英文别名:
- CS-2563;PNU 74654;PNU74654; PNU 74654;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
- 中文名:
- PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
- 中文别名:
- PNU 74654,WNT信号通路阻滞剂;N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼;N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼;WNT/Β-CATENIN通路抑制剂(PNU-74654);(E)-N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼
- CBNumber:
- CB82518792
- 分子式:
- C19H16N2O3
- 分子量:
- 320.34
- MOL File:
- 113906-27-7.mol
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PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE化学性质
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密度:
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1.17±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: >10mg/mL
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酸度系数(pKa):
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12.12±0.46(Predicted)
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形态:
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solid
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颜色:
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white to off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE性质、用途与生产工艺
PNU-74654是Wnt/β-catenin通路的的抑制剂，在NCI-H295 细胞中的IC50值为129.8 μM。
129.8 μM (Wnt/β-catenin, NCI-H295 cell)
PNU-74654 binds to β-catenin with a K
D
of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot. In NCI-H295 cells,PNU-74654 significantly decreases cell proliferation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol, testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but does not decrease cell viability.
PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-101130 | PNU-74654 | | 1 mg | 212元 |
| 2024/01/25 | HY-101130 | PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
PNU-74654 | 113906-27-7 | 5mg | 530元 |
PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
生产厂家
113906-27-7, PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE 相关搜索:
- 药靶配体
- 细胞生物学试剂
- N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼
- PNU 74654,WNT信号通路阻滞剂
- N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼
- WNT/Β-CATENIN通路抑制剂(PNU-74654)
- (E)-N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼
- 113906-27-7
- N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide
- N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide
- CS-2563
- PNU74654; PNU 74654
- PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
- Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide
- PNU 74654
- 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide