阿拉莫林盐酸盐
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- CAS号:
- 861998-00-7
- 英文名:
- AnaMorelin hydrochloride
- 英文别名:
- RC 1291 HCl;AnaMorelin HCl;RC 1291 hydrochloride;ONO-7643 hydrochloride;Alamorim hydrochloride;AnaMorelin hydrochloride;Anamorelin (RC-1291) HCl;Anamorelin Monohydrochloride;Anamorelin (RC-1291) hydrochloride;Anamorelin hydrochloride
(RC-1291 hydrochloride
- 中文名:
- 阿拉莫林盐酸盐
- 中文别名:
- 盐酸阿拉莫林;阿拉莫林盐酸盐;饥饿素受体(GHRELIN RECEPTOR)激动剂(ANAMORELIN HYDROCHLORIDE)
- CBNumber:
- CB82582827
- 分子式:
- C31H43ClN6O3
- 分子量:
- 583.16452
- MOL File:
- 861998-00-7.mol
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阿拉莫林盐酸盐化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:28.0(Max Conc. mg/mL);48.01(Max Conc. mM)
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形态:
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Powder
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阿拉莫林盐酸盐性质、用途与生产工艺
Anamorelin (RC-1291) hydrochloride 是一种有效的 ghrelin receptor 激动剂，FLIPR 检测中，EC50 为 0.74 nM。
Ki: 0.7 nM (ghrelin receptor)
EC50: 0.74 nM (ghrelin receptor)
In the FLIPR assay, Anamorelin (ANAM) shows significant agonist activity on the ghrelin receptor, with EC
50
value of 0.74 nM. No significant antagonist activity is observed with Anamorelin at concentrations of up to 1,000 nM. In the binding experiments, Anamorelin binds to the ghrelin receptor with a binding affinity constant (K
i
) of 0.70 nM. In the competition assay with radiolabeled ibutamoren (
35
S-MK-677; another ghrelin receptor agonist) Anamorelin (ANAM) is also found to bind with high affinity to the ghrelin receptor (IC
50
=0.69 nM). In rat pituitary cells incubated with Anamorelin, there is a dose-dependent stimulatory effect on GH release and the potency (EC
50
) is 1.5 nM. Anamorelin is screened for activity against a set of over 100 receptors, ion channels, transporters, and enzymes. Anamorelin demonstrates binding to the tachykinin neurokinin 2 (NK
2
) site (IC
50
=0.021 μM); however, a subsequent NK
2
functional assay demonstrates no functional activity.
In rats, Anamorelin (ANAM) at an oral dose of 3, 10, or 30 mg/kg once daily significantly increases both food intake and body weight from Day 2 to Day 7 of treatment compared with the vehicle control. The cumulative change in food intake and weight gain increases dose-dependently, and these changes are significant at all dose levels (P<0.05) compared to the control. Administration of Anamorelin at a single oral dose of 3, 10, or 30 mg/kg induces a dose-dependent increase in plasma GH levels and GH AUC
0-6h
in rats.
阿拉莫林盐酸盐
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14734A | Anamorelin hydrochloride | | 1 mg | 320元 |
| 2024/01/25 | HY-14734A | 阿拉莫林盐酸盐
Anamorelin hydrochloride | 861998-00-7 | 5mg | 1000元 |
861998-00-7, 阿拉莫林盐酸盐 相关搜索:
- 化学试剂
- 医药原料
- 医用原料
- 医药原料药-科研原料
- 医用原料
- 细胞生物学试剂
- C31H42N6O3HCl
- 饥饿素受体(GHRELIN RECEPTOR)激动剂(ANAMORELIN HYDROCHLORIDE)
- 盐酸阿拉莫林
- 阿拉莫林盐酸盐
- 861998-00-7
- Anamorelin Monohydrochloride
- Inhibitor,inhibit,ONO-7643,ONO 7643,RC-1291,GHSR,Growth hormone secretagogue receptor,ONO7643,Anamorelin,AnaMorelin hydrochloride,RC1291,RC 1291
- Alamorim hydrochloride
- 2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide,hydrochloride
- Anamorelin (RC-1291) hydrochloride
- RC-1291 HYDROCHLORIDE;ONO-7643 HYDROCHLORIDE;RC1291 HYDROCHLORIDE;ONO7643 HYDROCHLORIDE;RC 1291 HYDROCHLORIDE;ONO 7643 HYDROCHLORIDE
- Anamorelin hydrochloride
(RC-1291 hydrochloride
- Anamorelin (RC-1291) HCl
- RC 1291 HCl
- (3R)-1-(2-Methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid trimethylhydrazide monohydrochloride
- AnaMorelin HCl
- RC 1291 hydrochloride
- ONO-7643 hydrochloride
- AnaMorelin hydrochloride