网站主页 >> CAS数据库列表 >> 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
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- CAS号:
- 1125758-85-1
- 英文名:
- A 804598
- 英文别名:
- CS-2234;A 804598;A-804598 （(A 804598;S-2-Cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine;1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine;2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine;N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine;Guanidine, N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-
- 中文名:
- 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
- 中文别名:
- 化合物CZC25146;A-804598游离态;A 804598,P2X7拮抗剂;S-2-氰基-1-(1-苯乙基)-3-(喹啉-5-基)胍
- CBNumber:
- CB82602998
- 分子式:
- C19H17N5
- 分子量:
- 315.37
- MOL File:
- 1125758-85-1.mol
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1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE化学性质
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沸点:
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498.0±47.0 °C(Predicted)
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密度:
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1.17±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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酸度系数(pKa):
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4.52±0.12(Predicted)
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形态:
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powder
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颜色:
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white to beige
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1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE性质、用途与生产工艺
A-804598 是一个 CNS 渗透，竞争性和选择性的 P2X7 受体拮抗剂，作用于小鼠，大鼠和人的 P2X7 受体，IC50s 分别是 9 nM, 10 nM 和 11 nM。
IC50: 9 nM (mouse P2X7 receptor), 10 nM (rat P2X7 receptor), 11 nM (human P2X7 receptor)
Pre-incubation with A-804598 (0.1-10 μM; 1 hour) significantly attenuates BzATP-induced cell loss in a concentration-dependent manner. 3 μM A-804598 exhibits the greatest protective effect against BzATP-induced cytotoxicity.
Cell Cytotoxicity Assay
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Cell Line:
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microglial cell
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Concentration:
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0.1, 0.3, 1, 3, 10 μM
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Incubation Time:
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1 hour
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Result:
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Protected against BzATP-induced cytotoxicity in both inactivated and activated microglia.
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A chroni treatment with A-804598 (intraperitoneal injection; 30 mg/kg; five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease.
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Animal Model:
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Adult B6.Cg-Tg (SOD1-G93A) 1Gur/J female mice
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Dosage:
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30 mg/kg
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Administration:
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Intraperitoneal injection; five times a week
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Result:
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Decreased SQSTM1/p62 expression.
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1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-100483 | A-804598 | | 1 mg | 300元 |
| 2024/01/25 | HY-100483 | 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
A-804598 | 1125758-85-1 | 5mg | 550元 |
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
生产厂家
1125758-85-1, 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 相关搜索:
- 合成有机化合物配体
- A 804598,P2X7拮抗剂
- S-2-氰基-1-(1-苯乙基)-3-(喹啉-5-基)胍
- 化合物CZC25146
- A-804598游离态
- 1125758-85-1
- S-2-Cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine
- Guanidine, N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-
- CS-2234
- A-804598 （(A 804598
- 2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine
- 1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine
- N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine
- A 804598