化合物 T24524
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- CAS号:
- 439571-48-9
- 英文名:
- NDT 9513727
- 英文别名:
- NDT 9513727;N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine;1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-
- 中文名:
- 化合物 T24524
- 中文别名:
- 化合物 T24524;无损检测9513727;N,N-双(1,3-苯并二恶唑-5-甲基)-1-丁基-2,4-二苯基-1H-咪唑-5-甲胺
- CBNumber:
- CB82603001
- 分子式:
- C36H35N3O4
- 分子量:
- 573.68
- MOL File:
- 439571-48-9.mol
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化合物 T24524化学性质
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沸点:
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723.1±62.0 °C(Predicted)
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密度:
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1.23±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 100 mM; Ethanol: 100 mM
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形态:
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A solid
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酸度系数(pKa):
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6.69±0.50(Predicted)
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化合物 T24524性质、用途与生产工艺
NDT 9513727 是一种高效的，选择性的，具有口服活性的，竞争性的人 C5aR 反向激动剂，其 IC50 值为 11.6 nM。NDT 9513727 可用于人炎症疾病的研究。
IC50: 11.6 nM (human C5aR)
NDT 9513727 inhibits C5a-stimulated responses, including guanosine 5'-3-O-(thio)triphosphate binding, Ca
2+
mobilization, oxidative burst, degranulation, cell surface CD11b expression and chemotaxis in various cell types with IC
50
s from 1.1 to 9.2 nM, respectively.
NDT 9513727 (3-30 mg/kg; p.o.) exhibits a dose-dependent inhibition of hC5a-induced neutropenia.
NDT 9513727 exhibits moderate oral bioavailability (rat 73%, monkey 26%) and C
max
(rat 5.98 μM, monkey 830 nM) following oral administration (rat 50, monkey 25.2 mg/kg).
NDT 9513727 exhibits moderate plasma elimination half-lives (rat 4.8, monkey 7.9 h) due to low plasma clearance (1.4 L/h/kg and 3.8 l/h/kg respectively) following oral administration (rat 50, monkey 25.2 mg/kg).
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Animal Model:
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Six-week-old Mongolian gerbils
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Dosage:
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1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg
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Administration:
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Oral administration
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Result:
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Significantly inhibited hC5a-induced neutropenia at 3 mg/kg, 10 mg/kg, 30 mg/kg.
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Animal Model:
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Rat
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Dosage:
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50 mg/kg
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Administration:
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Oral administration
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Result:
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Oral bioavailability (73%), C
max
(5.98 μM), T
1/2
(4.8 h).
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Animal Model:
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Monkey
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Dosage:
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25.2 mg/kg
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Administration:
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Oral administration
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Result:
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Oral bioavailability (26%), C
max
(830 nM), T
1/2
(7.9 h).
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化合物 T24524
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-110060 | NDT 9513727 | | 5 mg | 800元 |
| 2024/01/25 | HY-110060 | 化合物 T24524
NDT 9513727 | 439571-48-9 | 10mg | 1360元 |
439571-48-9, 化合物 T24524 相关搜索:
- Agonist, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- 小分子
- 无损检测9513727
- N,N-双(1,3-苯并二恶唑-5-甲基)-1-丁基-2,4-二苯基-1H-咪唑-5-甲胺
- 化合物 T24524
- 439571-48-9
- 1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-
- N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine
- NDT 9513727