Gap 27
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- CAS号:
- 198284-64-9
- 英文名:
- GAP 27
- 英文别名:
- GAP 27;Gap 27（TFA);GAP 27, >98%;GAP-27; GAP27;SRPTEKTIFIIRPTEKTIFII;M.W. 1304.55 C60H101N15O17;Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile;Gap 27，Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile;Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, >98%;Gap27,inhibit,Inhibitor,Gap-27,Gap 27,Gap Junction Protein
- 中文名:
- Gap 27
- 中文别名:
- GAP27肽;缝隙连接蛋白多肽;GAP 27(三氟乙酸盐)
- CBNumber:
- CB8261625
- 分子式:
- C60H101N15O17
- 分子量:
- 1304.53
- MOL File:
- 198284-64-9.mol
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Gap 27化学性质
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密度:
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1.40±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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Soluble at 1mg/ml in 1% acetic acid
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酸度系数(pKa):
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3.41±0.10(Predicted)
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形态:
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Solid
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水溶解性:
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Soluble to 1 mg/ml in water
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序列:
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H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH
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Gap 27性质、用途与生产工艺
Gap 27，一种合成的 connexin43 模拟肽，是一种间隙连接抑制剂。Gap 27 与通往第二跨膜连接蛋白区段的第二细胞外环的一部分具有保守的序列同源性。
Gap 27 causes a remarked decrease in the number of both TRAP-positive mononuclear and multinucleated rat osteoclasts cultured on bovine bone slices. The activity of the remaining osteoclasts is found to be diminished by measuring the percentage of osteoclasts with actin rings of all TRAP-positive cells. In addition, the resorbed area in the treated cultures is greatly diminished. Incubation of the carotid artery with the gap junction inhibitor Gap 27 (500 μM) essentially abolishes the hyperpolarization to acetylcholine but it is without effect on that to levcromakalim. In the guinea-pig isolated internal carotid artery, Gap 27 inhibits acetylcholine-induced, endothelium-dependent hyperpolarizations.
Gap 27 (300 μM) inhibits relaxation by 40% in thoracic aorta and the superior mesenteric artery. Gap 27 also attenuates the endothelium-dependent component of the relaxation induced by ATP in thoracic aorta. .
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
Gap 27
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-P0139 | 198284-64-9
Gap 27 | 198284-64-9 | 1mg | 400元 |
| 2024/04/30 | HY-P0139 | 198284-64-9
Gap 27 | 198284-64-9 | 5mg | 950元 |
Gap 27
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全球有 93家供应商
Gap 27国内生产厂家
198284-64-9, Gap 27 相关搜索:
- Neuroscience
- Various Peptides
- Cytoskeleton and Extracellular Matrix
- Cell Signaling and Neuroscience
- Adhesion Molecules and Related Proteins
- 药靶配体
- 目录肽
- 多肽-目录肽
- 目录多肽
- 多肽
- Adhesion Molecules and Related Proteins
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Cytoskeleton and Extracellular Matrix
- C60H101N15O17
- C60H102N15O17
- GAP 27(三氟乙酸盐)
- GAP27肽
- 缝隙连接蛋白多肽
- 198284-64-9
- Gap 27（TFA)
- SRPTEKTIFIIRPTEKTIFII
- Gap 27，Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile
- Gap27,inhibit,Inhibitor,Gap-27,Gap 27,Gap Junction Protein
- GAP-27; GAP27
- GAP 27, >98%
- Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, >98%
- L-Isoleucine, L-seryl-L-arginyl-L-prolyl-L-threonyl-L-α-glutamyl-L-lysyl-L-threonyl-L-isoleucyl-L-phenylalanyl-L-isoleucyl-
- Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile
- M.W. 1304.55 C60H101N15O17
- GAP 27
- H-SER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE-OHSER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE