PDK1 抑制剂
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- CAS号:
- 1001409-50-2
- 英文名:
- PDK1 inhibitor
- 英文别名:
- MP7;PDK1 inhibitor;PDK1 inhibitor 7;2-dihydro-2-oxo-;4-difluorophenyl)methyl]-N-[(1R)-2-[(2;3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1;PDK1,MP7,inhibit,Inhibitor,MP 7,kinase-1,PDK-1,phosphoinositide-dependent,MP-7;1-[(3,4-Difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide;3-PyridinecarboxaMide, 1-[(3,4-difluorophenyl)Methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benziMidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-
- 中文名:
- PDK1 抑制剂
- 中文别名:
- PDK1 抑制剂;PDK1抑制剂(PDK1 INHIBITOR);1-[(3,4-二氟苯基)甲基]-N-[(1R)-2-[(2,3-二氢-2-氧代-1H-苯并咪唑-5-基)氧基]-1-苯基乙基]-1,2-二氢-2-氧代-3-吡啶甲酰胺
- CBNumber:
- CB82624271
- 分子式:
- C28H22F2N4O4
- 分子量:
- 516.5
- MOL File:
- 1001409-50-2.mol
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PDK1 抑制剂化学性质
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沸点:
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724.4±60.0 °C(Predicted)
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密度:
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1.398
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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酸度系数(pKa):
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11.48±0.20(Predicted)
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PDK1 抑制剂性质、用途与生产工艺
MP7 (PDK1 inhibitor) 是一种磷酸肌醇依赖性激酶-1 (PDK1) 抑制剂。
Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC
50
values in the micromolar range.
PDK1 抑制剂
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14440 | MP7 | | 1 mg | 590元 |
| 2024/01/25 | HY-14440 | PDK1 抑制剂
MP7 | 1001409-50-2 | 5mg | 1300元 |
1001409-50-2, PDK1 抑制剂 相关搜索:
- 细胞生物学试剂
- C28H22F2N4O4
- 1-[(3,4-二氟苯基)甲基]-N-[(1R)-2-[(2,3-二氢-2-氧代-1H-苯并咪唑-5-基)氧基]-1-苯基乙基]-1,2-二氢-2-氧代-3-吡啶甲酰胺
- PDK1抑制剂(PDK1 INHIBITOR)
- PDK1 抑制剂
- 1001409-50-2
- PDK1,MP7,inhibit,Inhibitor,MP 7,kinase-1,PDK-1,phosphoinositide-dependent,MP-7
- PDK1 inhibitor 7
- MP7
- 2-dihydro-2-oxo-
- 3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1
- 4-difluorophenyl)methyl]-N-[(1R)-2-[(2
- 3-PyridinecarboxaMide, 1-[(3,4-difluorophenyl)Methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benziMidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-
- 1-[(3,4-Difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide
- PDK1 inhibitor