D159687
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- CAS号:
- 1155877-97-6
- 英文名:
- 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea
- 英文别名:
- D159687;D159687; D-159687; D 159687;Inhibitor,inhibit,D159687,D-159687,Phosphodiesterase (PDE);[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea;1-(4-((3'-chloro-6-methoxybiphenyl-3-yl)methyl)phenyl)urea;1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea;1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea;Urea, N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-
- 中文名:
- D159687
- 中文别名:
- 化合物D 159687;1-(4-((3'-氯-6-甲氧基-[1,1'-联苯]-3-基)甲基)苯基)脲;1-(4-((3'-氯-6-甲氧基-[1,1'-联苯]-3-基)甲基)苯基)脲
- CBNumber:
- CB82642455
- 分子式:
- C21H19ClN2O2
- 分子量:
- 366.84
- MOL File:
- 1155877-97-6.mol
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D159687化学性质
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沸点:
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502.0±50.0 °C(Predicted)
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密度:
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1.263±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO : 150 mg/mL (408.90 mM)
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酸度系数(pKa):
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14.48±0.50(Predicted)
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D159687性质、用途与生产工艺
D159687 是一种选择性 PDE4D 抑制剂。
D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment.
D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM.
Western Blot Analysis
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Cell Line:
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HT-22 (mouse hippocampal cell line)
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Concentration:
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1 μM
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Incubation Time:
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0, 1, 3, 6, 12, 24 hours
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Result:
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Induced a transient increase in CREB phosphorylation which peaked at 6 hours after treatment.
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Western Blot Analysis
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Cell Line:
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HT-22 (mouse hippocampal cell line)
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Concentration:
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0.01 μM, 0.1 μM, 1 μM
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Incubation Time:
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6 hours
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Result:
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CREB phosphorylation was optimal at 1 μM.
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D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques.
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Animal Model:
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Female Cynomolgus macaques (4–6 year old)
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Dosage:
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0.05, 0.5, 5 mg/kg
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Administration:
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Oral daily for a week
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Result:
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A potential recruitment or enhancement of synaptic function with increased task difficulty.
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D159687
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-15444 | D159687
D159687 | 1155877-97-6 | 5mg | 600元 |
| 2024/01/25 | HY-15444 | D159687
D159687 | 1155877-97-6 | 10mM * 1mLin DMSO | 660元 |
1155877-97-6, D159687 相关搜索:
- 药靶配体
- 1-(4-((3'-氯-6-甲氧基-[1,1'-联苯]-3-基)甲基)苯基)脲
- 化合物D 159687
- 1-(4-((3'-氯-6-甲氧基-[1,1'-联苯]-3-基)甲基)苯基)脲
- 1155877-97-6
- 1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea
- Inhibitor,inhibit,D159687,D-159687,Phosphodiesterase (PDE)
- [4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea
- Urea, N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-
- D159687; D-159687; D 159687
- 1-(4-((3'-chloro-6-methoxybiphenyl-3-yl)methyl)phenyl)urea
- D159687
- 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea