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NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE
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- CAS号:
- 136719-25-0
- 英文名:
- NB598 hydrochloride
- 英文别名:
- NB598 hydrochloride;NB 598 hydrochloride;NB-598 (hydrochloride);NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE
- 中文名:
- NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE
- 中文别名:
- 化合物 T12199L
- CBNumber:
- CB82666666
- 分子式:
- C27H32ClNOS2
- 分子量:
- 486.13
- MOL File:
- 136719-25-0.mol
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NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO
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形态:
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Powder
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NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE性质、用途与生产工艺
NB-598是鲨烯环氧化酶(SE)竞争性抑制剂,能抑制甘油三酯的生物合成。
NB598 (10 μM) causes a 36±7% reduction in total cholesterol level of MIN6 cells. NB598 causes a significant decrease in cholesterol by 49±2%, 46±7%, and 48±2% from PM, ER, and SG, respectively. NB598 dose-dependently inhibits insulin secretion under both basal (1 mM glucose) and glucose-stimulated (16.7 mM glucose) conditions. NB598 at concentrations up to 10 μM does not affect peak outward KV currents or the voltage dependence of activation but increases current inactivation. NB-598 (10 μM) inhibits the synthesis of sterol and sterol ester from [
14
C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). In the absence of exogenous liposomal cholesterol, NB-598 reduces ACAT activity by 31%. NB-598 reduces ACAT activity by 22% even in the presence of a 600 PM concentration of liposomal cholesterol. NB-598 suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells into the medium.
NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE
生产厂家
136719-25-0, NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE 相关搜索:
- C27H32ClNOS2
- 化合物 T12199L
- 136719-25-0
- NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE
- NB598 hydrochloride
- NB-598 (hydrochloride)
- NB 598 hydrochloride