SJB2-043
|
|
|
- CAS号:
- 63388-44-3
- 英文名:
- SJB2-043
- 英文别名:
- SJB2-043;2-Phenylnaphth[2,3-d]oxazole-4,9-dione;2-Phenylnaphtho[2,3-d]oxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-phenyl-;2-phenylbenzo[f][1,3]benzoxazole-4,9-dione;SJB2-043,inhibit,DUBs,SJB2043,SJB-2-043,SJB2 043,Deubiquitinase,Inhibitor
- 中文名:
- SJB2-043
- 中文别名:
- 2-苯基萘并[2,3-D]恶唑-4,9-二酮;SJB2-043,抑制 USP1/UAF1 复合体;USP1/UAF1复合体抑制剂(SJB2-043)
- CBNumber:
- CB82666686
- 分子式:
- C17H9NO3
- 分子量:
- 275.26
- MOL File:
- 63388-44-3.mol
|
|
|
SJB2-043化学性质
-
熔点:
-
>290℃
-
|
-
沸点:
-
495.0±48.0 °C(Predicted)
-
|
-
密度:
-
1.373±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Sealed in dry,Room Temperature
-
|
-
溶解度:
-
insoluble in H2O; insoluble in EtOH; ≥4.62 mg/mL in DMSO
-
|
-
形态:
-
solid
-
|
-
酸度系数(pKa):
-
-3.87±0.20(Predicted)
-
|
SJB2-043性质、用途与生产工艺
SJB2-043是有效的USP1抑制剂，可抑制天然USP1/UAF1的活性，IC50为544 nM。
SJB2-043 是一种有效的 USP1 的抑制剂，可抑制天然 USP1/UAF1 的活性，对应的IC50值为544 nM。
| Target | Value |
USP1-UAF1
(Cell-free assay)
|
544 nM
|
SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC
50
of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner.
SJB2-043
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15757 | SJB2-043
SJB2-043 | 63388-44-3 | 5mg | 950元 |
| 2024/01/25 | HY-15757 | SJB2-043
SJB2-043 | 63388-44-3 | 10mM * 1mLin DMSO | 1045元 |
63388-44-3, SJB2-043 相关搜索:
- 合成有机化合物配体
- 抑制剂
- 细胞生物学试剂
- SJB2-043,抑制 USP1/UAF1 复合体
- USP1/UAF1复合体抑制剂(SJB2-043)
- 2-苯基萘并[2,3-D]恶唑-4,9-二酮
- 63388-44-3
- SJB2-043,inhibit,DUBs,SJB2043,SJB-2-043,SJB2 043,Deubiquitinase,Inhibitor
- 2-Phenylnaphtho[2,3-d]oxazole-4,9-dione
- Naphth[2,3-d]oxazole-4,9-dione, 2-phenyl-
- 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
- 2-Phenylnaphth[2,3-d]oxazole-4,9-dione
- SJB2-043