HDAC6抑制剂
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- CAS号:
- 1429651-50-2
- 英文名:
- HPOB
- 英文别名:
- HPOB;CS-1829;HPOB,HDAC6 inhibitor;N-hydroxy-4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)benzamide;4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide;Benzeneacetamide, 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-;4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl- benzeneacetamide HPOB
- 中文名:
- HDAC6抑制剂
- 中文别名:
- 化合物HPOB;HDAC6抑制剂(HPOB);N-羟基-4-(2-((2-羟乙基)(PH苯基)氨基)-2-氧乙基)苯甲酰胺
- CBNumber:
- CB82730376
- 分子式:
- C17H18N2O4
- 分子量:
- 314.34
- MOL File:
- 1429651-50-2.mol
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HDAC6抑制剂化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble1mg/mL, clear (warmed)
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形态:
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powder
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颜色:
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white to beige
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HDAC6抑制剂性质、用途与生产工艺
HPOB是一种有效的,选择性 HDAC6抑制剂,IC50为56 nM,选择性比对其它HDACs高30多倍。
In normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells.
In mice bearing CWR22 human prostate cancer xenografts, HPOB (300 mg/kg/d i.p.), when in combination with SAHA, causes suppression of the growth of established tumors, while produces no significant suppression when used alone.
HDAC6抑制剂
上下游产品信息
上游原料
下游产品
1429651-50-2, HDAC6抑制剂 相关搜索:
- Inhibitors
- 药靶配体
- 标准品
- 细胞生物学试剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- N-羟基-4-(2-((2-羟乙基)(PH苯基)氨基)-2-氧乙基)苯甲酰胺
- 化合物HPOB
- HDAC6抑制剂(HPOB)
- 1429651-50-2
- HPOB,HDAC6 inhibitor
- Benzeneacetamide, 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-
- CS-1829
- 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide
- 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl- benzeneacetamide HPOB
- N-hydroxy-4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)benzamide
- HPOB