CS-2394
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- CAS号:
- 686772-17-8
- 英文名:
- IWP 4
- 英文别名:
- IWP 4;CS-2394;IWP4;IWP 4;IWP-4 >=95% (HPLC);Wnt Inhibitor IWP-4;Inhibitor of Wnt Production-4;IWP-4,inhibit,IWP 4,Inhibitor,Wnt,IWP4;N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide;Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-;2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- 中文名:
- CS-2394
- 中文别名:
- 化合物IWP 4;2-((3-(2-甲氧基苯基)-4-氧代-3,4,6,7-四氢噻吩并[3,2-D]嘧啶-2-基)硫代)-N-(6-甲基苯并[D]噻唑-2-基)乙酰胺
- CBNumber:
- CB82748092
- 分子式:
- C23H20N4O3S3
- 分子量:
- 496.62
- MOL File:
- 686772-17-8.mol
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CS-2394化学性质
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密度:
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1.51±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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insoluble in H2O; insoluble in EtOH; insoluble in DMSO
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酸度系数(pKa):
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9.01±0.70(Predicted)
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形态:
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powder
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颜色:
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white to light brown
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CS-2394性质、用途与生产工艺
IWP-4 是一种小分子 Wnt 抑制剂，其 IC50 值为 25 nM。
IWP-4 is a small molecule Wnt inhibitor with an IC
50
of 25 nM. IWP-4 induces the expression of cardiac markers, including cardiac troponin I (CTNI) and cardiac myosin heavy chain bright cells (MYH
hi +
). IWP-4 also results in the appearance of beating foci (0.44±0.10 SEM beats per second), which is absent in all cultures not receiving IWP-4. Further, flow cytometric analysis shows that there are significantly more MYH
lo +
cells in IWP-4 treated cultures (P<0.0002) compare with untreated cultures at day 16, being 17.0±1.3 SD% and 5.4±1.4 SD%, respectively. Quantification of NKX2-5 protein expression shows that 63% (481/817) of IWP-4 treated cells display nuclear NKX2-5 expression. Mesenchymal precursor cells (MPCs) treated with IWP-4 show no significant changes in the expression of
AXIN2
,
CTNNB1
and
GSK3B
as compare to osteogenic medium alone on day 7, but MPCs treated with IWP-4 express elevates levels of
DKK1
and
GSK3β
on day 21. IWP-4 also causes a significant down regulation of
SPARC
and
COL1A1
.
CS-2394
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-12879 | IWP-4 | | 1 mg | 438元 |
| 2024/01/25 | HY-12879 | CS-2394
IWP-4 | 686772-17-8 | 5mg | 1500元 |
686772-17-8, CS-2394 相关搜索:
- 抑制剂
- C23H20N4O3S3
- 化合物IWP 4
- 2-((3-(2-甲氧基苯基)-4-氧代-3,4,6,7-四氢噻吩并[3,2-D]嘧啶-2-基)硫代)-N-(6-甲基苯并[D]噻唑-2-基)乙酰胺
- 686772-17-8
- IWP-4,inhibit,IWP 4,Inhibitor,Wnt,IWP4
- IWP-4 >=95% (HPLC)
- Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-
- Inhibitor of Wnt Production-4
- CS-2394
- IWP4;IWP 4
- N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
- 2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- Wnt Inhibitor IWP-4
- IWP 4