MPP 二盐酸盐
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- CAS号:
- 911295-24-4
- 英文名:
- Methyl-piperidino-pyrazole hydrate
- 英文别名:
- MPP dihydrochloride hydrate;Methyl-piperidino-pyrazole hydrate;MPP dihydrochloride (289726-02-9 Free base);Methyl-piperidino-pyrazole dihydrochloride hydrate;MPP dihydrochloride (289726029 Free base),MPP dihydrochloride (289726 02 9 Free base);4,4'-(4-Methyl-5-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1H-pyrazole-1,3-diyl)diphenol dihydrochloride;1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride hydrate
- 中文名:
- MPP 二盐酸盐
- 中文别名:
- MPP 二盐酸盐;化合物 T12101;化合物MPP DIHYDROCHLORIDE (289726-02-9 FREE BASE);4,4'-(4-甲基-5-(4-(2-(哌啶-1-基)乙氧基)苯基)-1H-吡唑-1,3-二基)二苯酚二盐酸盐
- CBNumber:
- CB82750408
- 分子式:
- C29H32ClN3O3
- 分子量:
- 506.04
- MOL File:
- 911295-24-4.mol
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MPP 二盐酸盐化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: soluble ≥20mg/mL
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形态:
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white powder
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MPP 二盐酸盐性质、用途与生产工艺
MPP dihydrochloride 是一种高度选择性的雌激素受体 α (ERα) 拮抗剂。MPP dihydrochloride 降低了 p-ERα/ERα 的比率。
MPP (1, 5, 10, 25, 50 and 100 µM; 24 h) decreases cell viability with an IC
50
value of 20.01 µM in RL95-2 cells.
MPP dihydrochloride shows antiproliferative activity at a concentration of 10 μM in RL95-2 cells.
MPP dihydrochloride (20 µM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα.
Cell Viability Assay
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Cell Line:
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RL95-2 endometrium cancer cells
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Concentration:
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1, 5, 10, 25, 50 and 100 µM
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Incubation Time:
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24 hours
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Result:
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The treatment with 25 µM, 50 µM and 100 µM for 24 h decreased cell viability significantly. However, cell viability was not significantly changed by MPP dihydrochloride at concentration below 25 µM.
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Cell Proliferation Assay
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Cell Line:
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RL95-2 cell
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Concentration:
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10, 15, 20 and 25 µM
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Incubation Time:
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72 hours
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Result:
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Showed antiproliferative activity at a concentration of 10 μM.
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Western Blot Analysis
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Cell Line:
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RL95-2 cell line
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Concentration:
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20 µM
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Incubation Time:
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24 hours
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Result:
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Reduced the phosphorylation of ERα, while it did not alter the phosphorylation of Akt. Reduced the ratio of p-ERα/ERα compared to the control group.
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MPP (Low dose 20 μg/kg body weight or high dose 200 μg/kg body weight) leads to a dose-dependent attenuation of percent prepulse inhibition (PPI).
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Animal Model:
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Male C57BL/6N mice at the age of 9-10 weeks
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Dosage:
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Low dose (20 μg/kg body weight) or high dose (200 μg/kg body weight)
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Administration:
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Administered subcutaneously (s.c.) injected; injection volume of 5 mL/kg; 60 min before PPI testing
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Result:
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Led to a dose-dependent attenuation of percent PPI. Pretreatment with 200 μg/kg reduced the mean percent PPI scores by ~30%.
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MPP 二盐酸盐
上下游产品信息
上游原料
下游产品
911295-24-4, MPP 二盐酸盐 相关搜索:
- 药靶配体
- 4,4'-(4-甲基-5-(4-(2-(哌啶-1-基)乙氧基)苯基)-1H-吡唑-1,3-二基)二苯酚二盐酸盐
- 化合物MPP DIHYDROCHLORIDE (289726-02-9 FREE BASE)
- 化合物 T12101
- MPP 二盐酸盐
- 911295-24-4
- 4,4'-(4-Methyl-5-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1H-pyrazole-1,3-diyl)diphenol dihydrochloride
- MPP dihydrochloride (289726029 Free base),MPP dihydrochloride (289726 02 9 Free base)
- MPP dihydrochloride (289726-02-9 Free base)
- Methyl-piperidino-pyrazole dihydrochloride hydrate
- Methyl-piperidino-pyrazole hydrate
- MPP dihydrochloride hydrate
- 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride hydrate